{
  "abstract": "Background In animal models, transplacental transfer of NMDAR-IgG has been shown to adversely affect foetal neurodevelopment. However, case reports of pregnancy complicated by NMDAR antibody encephalitis (NMDAR-Ab-E) have been more reassuring. Thus, the exact maternal/foetal effects of NMDAR-Ab-E complicating pregnancy remain unknown.Methods We systematically reviewed published cases of NMDAR-Ab-E with an onset before, during or after pregnancy. These were compared to our own experience as a specialist centre. Full-text preprint available from MEDRXIV/2024/317822.Results We identified 66 pregnancies amongst 61 women, with the majority resulting in livebirth (80%, 53/66) and recovery with minimal or no maternal deficit (72%, 44/61). Seven neonates were compromised at birth, with one neonatal death. Childhood follow-up was available in 60% of cases, however where available showed good outcomes with only one case of global developmental delay. This is in keeping with our own experience, where 75% (3/4) mothers recovered with no deficit and 88% (7/8) of children had normal development. However, overall assessment is limited by lack of follow-up and frequent missing data, for example only 25% of cases included birthweight.Conclusions Whilst current data is reassuring these significant caveats prevent firm conclusions. These could be addressed through the development of an international registry.sophie.binks@ndcn.ox.ac.uk",
  "authors": [
    {
      "affiliations": [
        "Medical Sciences Division, University of Oxford, UK",
        "Faculty of Medicine, Imperial College London, UK"
      ],
      "name": "Harris Scarlett L"
    },
    {
      "affiliations": [
        "Oxford Autoimmune Neurology Group, Nuffield Dept of Clinical Neurosciences, University of Oxford",
        "Department of Neurology, Oxford University Hospital NHS Foundation Trust, UK"
      ],
      "name": "Binks Sophie NM"
    },
    {
      "affiliations": [
        "Oxford Autoimmune Neurology Group, Nuffield Dept of Clinical Neurosciences, University of Oxford",
        "Department of Neurology, Oxford University Hospital NHS Foundation Trust, UK"
      ],
      "name": "Skelly Donal"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynaecology, Oxford University Hospital NHS Foundation Trust, UK"
      ],
      "name": "Fourie Hanine"
    },
    {
      "affiliations": [
        "Medical Sciences Division, University of Oxford, UK"
      ],
      "name": "Cherrington-Walke Phoebe"
    },
    {
      "affiliations": [
        "Department of Psychological Medicine, Oxford University Hospital NHS Foundation Trust, UK"
      ],
      "name": "Bajorek Tomasz"
    },
    {
      "affiliations": [
        "Oxford Autoimmune Neurology Group, Nuffield Dept of Clinical Neurosciences, University of Oxford",
        "Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, Florida, USA"
      ],
      "name": "Irani Sarosh R"
    },
    {
      "affiliations": [
        "Oxford Autoimmune Neurology Group, Nuffield Dept of Clinical Neurosciences, University of Oxford",
        "Department of Neurology, Oxford University Hospital NHS Foundation Trust, UK"
      ],
      "name": "Leite M Isabel"
    },
    {
      "affiliations": [
        "Oxford Autoimmune Neurology Group, Nuffield Dept of Clinical Neurosciences, University of Oxford",
        "Department of Neurology, Oxford University Hospital NHS Foundation Trust, UK"
      ],
      "name": "Handel Adam E"
    },
    {
      "affiliations": [
        "Department of Psychiatry, University of Oxford, UK"
      ],
      "name": "Al-Diwani Adam"
    }
  ],
  "title": "153 A systematic review of clinical outcomes and reporting quality in pregnancy-associated NMDAR-antibody encephalitis",
  "uid": "645f2c6d-9165-52a9-870d-9db160a2df8a"
}