{
  "abstract": "Bedside forced vital capacity (FVC) monitoring is the gold standard in detecting impending respiratory failure in patients with neuromuscular disease. However, bedside spirometry is often unavailable, especially in resource-limited settings, and facial muscle weakness can lead to unreliable measurements. In these settings the single breath count (SBC) is a potential alternative as it does not require specialised equipment nor is it affected by facial muscle weakness.However, uncertainties remain about its reliability in assessing patients with neuromuscular diseases such as myasthenia gravis in clinical practice.We compared SBC and FVC in 43 healthy adult volunteers and in 15 patients with seropositive myasthenia gravis in the outpatient setting. The myasthenic cohort, who were all anti-acetylcholine receptor antibody positive, had varying degrees of neuromuscular (bulbar and limb) weakness. Using linear regression, we showed a positive correlation between FVC and SBC in both healthy volunteers (R = 0.73, p<0.001) and myasthenia gravis patients (R= 0.59. P< 0.002). These results provide further evidence that SBC is a reliable and reproducible alternative FVC in settings where spirometry is unavailable.Khaizer.rizvi@nhs.net",
  "authors": [
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford"
      ],
      "name": "Rizvi Khaizer"
    },
    {
      "affiliations": [
        "Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London",
        "National Hospital for Neurology and Neurosurgery, London, UK"
      ],
      "name": "Aslanyan Aram"
    },
    {
      "affiliations": [
        "National Hospital for Neurology and Neurosurgery, London, UK"
      ],
      "name": "Boardman Jeremy"
    },
    {
      "affiliations": [
        "National Hospital for Neurology and Neurosurgery, London, UK"
      ],
      "name": "Glass Hannah"
    },
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford"
      ],
      "name": "Lilleker James B"
    },
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford"
      ],
      "name": "Mohanraj Rajiv"
    },
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford"
      ],
      "name": "Sussman Jon"
    },
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford"
      ],
      "name": "Dodd Katherine C"
    }
  ],
  "title": "57 Is single breath count a reliable surrogate marker for forced vital capacity in myasthenia gravis?",
  "uid": "3440710f-883e-5d44-8f31-2ea59fe2cea3"
}