{
  "abstract": "The initial presentation of prion diseases can mimic Alzheimer’s disease (AD). Recently revised AD diagnostic criteria state that a single abnormal highly-specific plasma biomarker (including p-tau217) is sufficient for diagnosis. We investigated the performance of AD plasma biomarkers in distinguishing AD and prion diseases.Plasma p-tau217, p-tau181, Aβ42/40 ratio, brain-derived tau (BD-tau), neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP) were measured using Simoa ultrasensitive immunoassay.We analysed 345 samples from 278 individuals, including 204 with prion diseases (121 sporadic CJD, 11 iatrogenic CJD, 9 variant CJD, 47 slow-progressing inherited prion disease (IPD) and 16 fast-progressing IPD), 30 with AD and 41 healthy controls.P-tau217 cannot discriminate prion diseases without concomitant AD neuropathology from AD (AUC [95%CI] 0.605 [0.486-0.724]), nor can p-tau181 (AUC 0.554 [0.446-0.661]) or GFAP (AUC 0.514 [0.389-0.640]). Aβ42/40 discriminates moderately (AUC 0.770 [0.684 - 0.856]). NfL/p-tau217 ratio discriminates near-perfectly (AUC 0.996 [0.987 – 1.000]) and NfL discriminates well (AUC 0.988 [0.974-1.000]) as does BD-tau (AUC 0.934 [0.890-0.978]).Diagnosis of AD on the basis of a single abnormal p-tau plasma AD biomarker would misdiagnose prion diseases as AD. Plasma NfL/p-tau217 ratio discriminates AD and prion diseases near-perfectly and could act as a flag to suspect prion diseases.thomas.coysh@nhs.net",
  "authors": [
    {
      "affiliations": [
        "Medical Research Council Prion Unit at University College London, UCL Institute of Prion Diseases",
        "NHS National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH, London"
      ],
      "name": "Coysh Thomas"
    },
    {
      "affiliations": [
        "UK Dementia Research Institute at University College London, London"
      ],
      "name": "Veleva Elena"
    },
    {
      "affiliations": [
        "UK Dementia Research Institute at University College London, London",
        "Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London"
      ],
      "name": "Heslegrave Amanda"
    },
    {
      "affiliations": [
        "Dementia Research Centre, UCL Queen Square Institute of Neurology, London"
      ],
      "name": "Keshavan Ashvini"
    },
    {
      "affiliations": [
        "UK Dementia Research Institute at University College London, London",
        "Dementia Research Centre, UCL Queen Square Institute of Neurology, London"
      ],
      "name": "Schott Jonathan M"
    },
    {
      "affiliations": [
        "Division of Neuropathology, National Hospital for Neurology and Neurosurgery, UCLH, London",
        "Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London"
      ],
      "name": "Jaunmuktane Zane"
    },
    {
      "affiliations": [
        "Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg",
        "Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden"
      ],
      "name": "Blennow Kaj"
    },
    {
      "affiliations": [
        "UK Dementia Research Institute at University College London, London",
        "Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London",
        "Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg",
        "Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden",
        "Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China"
      ],
      "name": "Zetterberg Henrik"
    },
    {
      "affiliations": [
        "Medical Research Council Prion Unit at University College London, UCL Institute of Prion Diseases",
        "NHS National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH, London"
      ],
      "name": "Collinge John"
    },
    {
      "affiliations": [
        "Medical Research Council Prion Unit at University College London, UCL Institute of Prion Diseases",
        "NHS National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH, London"
      ],
      "name": "Mead Simon"
    }
  ],
  "title": "112 Performance of alzheimer’s disease plasma biomarkers in prion diseases",
  "uid": "2966c7a3-d351-5c98-b137-d5ddd2d792ad"
}