{
  "abstract": "Introduction Multiple sclerosis commonly affects women of childbearing age. The UK MS Pregnancy Register was established in 2021 to inform clinical practice.Methods Structured questionnaires were completed by participants at specific timepoints during pregnancy and 3- and 12-months post-partum. Data up to November 2024 is presented.Results A total of 301 pregnancies were included with mean age at recruitment 34.4. Ninety percent (271) of participants had taken DMT at some point; 50% participants continued DMT into pregnancy and 31% planned to continue throughout pregnancy. Fourteen participants (5%) reported a relapse; 31% of those during pregnancy and 69% post-partum or following miscarriage. Eighty-six percent were on DMT at the time of relapse, most commonly glatiramer acetate. Average gestational age at birth was 39.3 weeks and 55% of participants were exclusively breastfeeding at 3 months, with 32% reporting that MS had affected their decision to breastfeed, with DMT use cited by a third. A medical issue at 3 months post-partum occurred in 16% infants, most frequently cow’s milk protein allergy. All infants with available data were meeting all expected milestones at 12 months.Discussion Pregnancy outcomes and developmental trajectories of infants born to people with MS appear similar to the general population, providing important reassurance. DMT use appears an important consideration in post-partum decision making, particularly breastfeeding.mariana.nbt@gmail.com",
  "authors": [
    {
      "affiliations": [
        "Centre for Preventive Neurology, Wolfson Institute of Population Health, QMUL, London, UK"
      ],
      "name": "Tregaskis-Daniels Emily"
    },
    {
      "affiliations": [
        "Centre for Preventive Neurology, Wolfson Institute of Population Health, QMUL, London, UK"
      ],
      "name": "Nalmpanti Mariana"
    },
    {
      "affiliations": [
        "UK MS Register, Population Data Science, Swansea University Medical School, Swansea, UK"
      ],
      "name": "Knowles Sarah"
    },
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Trust, Salford, UK"
      ],
      "name": "Rog David"
    },
    {
      "affiliations": [
        "Anne Rowling Regenerative Neurology Clinic, The University of Edinburgh, Edinburgh, UK",
        "Department of Neurology, Forth Valley Royal Hospital, Larbert, UK"
      ],
      "name": "Murray Katy"
    },
    {
      "affiliations": [
        "Department of Neurology, Belfast Health and Social Care Trust, Belfast, UK"
      ],
      "name": "Hughes Stella"
    },
    {
      "affiliations": [
        "Department of Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"
      ],
      "name": "Ford Helen L"
    },
    {
      "affiliations": [
        "Department of Neurology, Morriston Hospital, Swansea, UK"
      ],
      "name": "Pearson Owen R"
    },
    {
      "affiliations": [
        "Department of Neurology, King’s College Hospital NHS Foundation Trust, London, UK"
      ],
      "name": "Brex Peter"
    },
    {
      "affiliations": [
        "Centre for Preventive Neurology, Wolfson Institute of Population Health, QMUL, London, UK",
        "Department of Neurology, The Royal London Hospital, London, UK"
      ],
      "name": "Dobson Ruth"
    }
  ],
  "title": "169 Pregnancy and post-partum outcomes in multiple sclerosis: insights from the UK MS pregnancy register",
  "uid": "1f72f201-b9e8-51b5-baac-4b2311be338e"
}