{
  "abstract": "Diagnosing lymphomas can be challenging, particularly in atypical presentations lacking histological confirmation. We report two cases where next-generation sequencing of plasma cell-free DNA (cfDNA) enabled the early detection of diffuse large B-cell lymphoma, months before biopsy confirmation. cfDNA analysis identified key lymphoma-associated mutations, guiding diagnosis when conventional investigations were inconclusive. These findings highlight cfDNA’s potential as a non-invasive diagnostic tool for occult lymphoma. While further validation is needed, cfDNA may facilitate earlier intervention in challenging cases, improving patient outcomes.",
  "authors": [
    {
      "affiliations": [
        "Service d’hématologie biologique, Hospices Civils de Lyon, Lyon, France"
      ],
      "name": "Mathilde Bonnot"
    },
    {
      "affiliations": [
        "Service d’hématologie biologique, Hospices Civils de Lyon, Lyon, France"
      ],
      "name": "Pauline Bertin"
    },
    {
      "affiliations": [
        "Service de médecine interne, Centre Hospitalier de Mâcon, Mâcon, France"
      ],
      "name": "Thibault Maillet"
    },
    {
      "affiliations": [
        "Service de médecine interne, Centre Hospitalier de Mâcon, Mâcon, France"
      ],
      "name": "Nicolas Guyotat"
    },
    {
      "affiliations": [
        "Service de Génétique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de Dijon, Dijon, France"
      ],
      "name": "Julliane Bloch"
    },
    {
      "affiliations": [
        "Service d’hématologie clinique, Centre Hospitalier Universitaire de Dijon, Dijon, France"
      ],
      "name": "Steeve Chevreux"
    },
    {
      "affiliations": [
        "Service d’hématologie biologique, Hospices Civils de Lyon, Lyon, France"
      ],
      "name": "Isabelle Mosnier"
    },
    {
      "affiliations": [
        "Service d’hématologie clinique, Hospices Civils de Lyon, Lyon, France",
        "Team Lymphoma Immuno Biology, Centre International de Recherche en Infectiologie, Lyon, Auvergne-Rhône-Alpes, France"
      ],
      "name": "Hervé Ghesquières"
    },
    {
      "affiliations": [
        "Service de neurocognition et neuro-ophtalmologie, Hospices Civils de Lyon, Lyon, France"
      ],
      "name": "Audrey Pechenot"
    },
    {
      "affiliations": [
        "Service de neurocognition et neuro-ophtalmologie, Hospices Civils de Lyon, Lyon, France",
        "Faculty of Medicine, Université Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rhône-Alpes, France"
      ],
      "name": "Virginie Desestret"
    },
    {
      "affiliations": [
        "Service d’hématologie biologique, Hospices Civils de Lyon, Lyon, France",
        "Team Lymphoma Immuno Biology, Centre International de Recherche en Infectiologie, Lyon, Auvergne-Rhône-Alpes, France"
      ],
      "name": "Pierre Sujobert"
    },
    {
      "affiliations": [
        "Service d’hématologie biologique, Hospices Civils de Lyon, Lyon, France",
        "Team Lymphoma Immuno Biology, Centre International de Recherche en Infectiologie, Lyon, Auvergne-Rhône-Alpes, France"
      ],
      "name": "Sarah Huet"
    }
  ],
  "title": "Molecular sleuthing: unmasking hidden lymphomas through plasma DNA sequencing",
  "uid": "69252c7b-e1be-5955-9943-5ec03933973a"
}