{
  "abstract": "We read with interest the recent original paper by Benusiglio et al.1 The authors reported a series of 20 individuals at high risk for diffuse gastric cancer (DGC) with a documented germline CDH1 pathogenic variant. These individuals refused or were not eligible for prophylactic total gastrectomy (PTG) and opted for endoscopic surveillance every 6 or 12 months, in accordance with the Cambridge protocol. pT1a signet-ring cell carcinoma (SRCC) foci were identified in 6/20 patients during a mean follow-up of 62 months. However, none of these subjects developed an advanced DGC beyond >pT1a. Other studies reported similar results, but with a short follow-up.2 3",
  "authors": [
    {
      "affiliations": [
        "Breast Surgery, European Institute of Oncology, IRCCS, Milan, Italy",
        "Oncology and Hemato-oncology, University of Milan 'La Statale', Milan, Italy"
      ],
      "name": "Giovanni Corso"
    },
    {
      "affiliations": [
        "Clinical Sciences and Community Health, University of Milan, Milan, Italy"
      ],
      "name": "Carlo La Vecchia"
    }
  ],
  "title": "Decreasing diffuse gastric cancer risk in individuals with germline CDH1 pathogenic variants. What about prophylactic total gastrectomy?",
  "uid": "8a8dfa86-5248-55cf-b353-73a440e0fd02"
}