{
  "abstract": "Variants in iron metabolism genes have been implicated in Alzheimer Disease (AD) pathogenesis.1 2 Previous studies suggested that the joint effect of haemochromatosis (HFE) C282Y (rs1800562) and transferrin (TF) C2 (P589S, rs1049296) variants increases the risk for AD.3–5 We sought to replicate this finding in a genetically homogeneous Midwestern Amish population. Our analysis of 706 Amish individuals (529 cognitively unimpaired (CU) and 177 with AD) found no significant association between these variants, individually or in combination, and AD risk. This result is consistent with another large-scale AD study also aiming to replicate the same findings.6",
  "authors": [
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Yining Liu"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Yeunjoo E Song"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
        "Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Audrey Lynn"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Weihuan Wang"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Kristy Miskimen"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Sarada L Fuzzell"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Sherri D Hochstetler"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Renee A Laux"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Laura J Caywood"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Jason E Clouse"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Sharlene D Herington"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Ping Wang"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Alexander V Gulyayev"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA",
        "The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Daniel A Dorfsman"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Noel C Moore"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
        "Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Leighanne R Main"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Michael B Prough"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Andrew F Zaman"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Larry D Adams"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Patrice Whitehead"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA",
        "Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Paula Ogrocki"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA",
        "Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Alan J Lerner"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA",
        "The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Jeffery Vance"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA",
        "The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Michael L Cuccaro"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA",
        "The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "William K Scott"
    },
    {
      "affiliations": [
        "John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA",
        "The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA"
      ],
      "name": "Margaret A Pericak-Vance"
    },
    {
      "affiliations": [
        "Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA",
        "Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"
      ],
      "name": "Jonathan L Haines"
    }
  ],
  "title": "No association of Alzheimer disease with the joint effect of HFE and TF in the mid-western Amish",
  "uid": "e6c93eb5-f14a-5376-b783-a2895294c2d3"
}