{
  "abstract": "Background Overcoming tyrosine kinase inhibitor (TKI) resistance improves survival in advanced epidermal growth factor receptor ( EGFR)-mutated non-small-cell lung cancer (NSCLC). We therefore examined the safety and preliminary efficacy of pelcitoclax, a B-cell lymphoma-2 (BCL-2)/BCL-extra-large (BCL-xL) inhibitor, and osimertinib in patients with EGFR-mutated advanced NSCLC.Methods Enrolled patients included Cohort 1 (previously progressed after third-generation TKI treatment+chemotherapy), Cohort 2 (previously progressed after first-generation or second-generation TKI treatment+chemotherapy), and Cohort 3 (TKI treatment-naive±prior chemotherapy). Patients received intravenous pelcitoclax (160 mg in dose-expansion and either 160 or 240 mg in dose-escalation) weekly and oral osimertinib 80 mg daily. Primary endpoints were safety and recommended phase 2 dose (dose-escalation), objective response rate (ORR) and safety (dose-expansion).Results 64 patients were enrolled (13, dose-escalation; 51, dose-expansion): 29 patients in Cohort 1, 8 in Cohort 2, and 27 in Cohort 3. One dose-limiting toxicity occurred at pelcitoclax 240 mg, and the recommended phase 2 dose was 160 mg plus osimertinib 80 mg. The ORR was 10.7% and median progression-free survival (mPFS) 2.7 months in patients previously progressed after third-generation TKI treatment+chemotherapy (Cohort 1) and 80.8% and 16.4 months in TKI treatment-naïve patients±prior chemotherapy (Cohort 3). mPFS was longer in Cohort 1 patients with high expression of BCL-xL (4.2 vs 2.7 months, p=0.058).Conclusions Pelcitoclax combined with osimertinib showed promising safety and antitumor activity in EGFR-mutated NSCLC.Trial registration number NCT04001777.",
  "authors": [
    {
      "affiliations": [
        "Department of Clinical Research, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Yuxiang Ma"
    },
    {
      "affiliations": [
        "Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin, China"
      ],
      "name": "Chunjiao Wu"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China"
      ],
      "name": "Yan-Qiu Zhao"
    },
    {
      "affiliations": [
        "Department of Oncology, The First Hospital of Jilin University, Changchun, Jilin, China"
      ],
      "name": "Jiuwei Cui"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Yan Huang"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Wenfeng Fang"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Yunpeng Yang"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Yuanyuan Zhao"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China"
      ],
      "name": "Chen Yang"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China"
      ],
      "name": "Wentao Pan"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China"
      ],
      "name": "Dengkun Xiong"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China"
      ],
      "name": "Lichuang Men"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China"
      ],
      "name": "Hengbang Wang"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China",
        "Department of Experimental Research, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Dajun Yang"
    },
    {
      "affiliations": [
        "Ascentage Pharma, Suzhou, Jiangsu, China",
        "Ascentage Pharma Group, Rockville, Maryland, USA"
      ],
      "name": "Yifan Zhai"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Li Zhang"
    },
    {
      "affiliations": [
        "Department of Clinical Research, Sun Yat-sen University Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China"
      ],
      "name": "Hongyun Zhao"
    }
  ],
  "title": "BCL-2/BCL-xL inhibitor pelcitoclax with osimertinib for EGFR-mutated advanced non-small-cell lung cancer: a phase 1b trial",
  "uid": "5b3ea45f-16a0-558f-85fe-67ad3c03328a"
}