{
  "abstract": "Clinical trials of adoptive cellular therapy demonstrate that a key characteristic associated with durable responses is in vivo expansion and persistence of transferred T cells. Strategies to develop a less differentiated, stem/memory population in the infusion product and peri-infusional regimens to promote the maintenance of desired T cell states following adoptive transfer would be desirable. Endogenous T cell therapy studies have routinely achieved memory T cells enriched for expression of interleukin (IL)-7 receptor; to eliminate the conventional requirement for immunosuppressive lymphodepletion and its attendant life-threatening toxicities, we performed the first-in-human use of IL-7 in combination with adoptively transferred antigen-specific memory CD8 T cells in a patient with refractory metastatic uveal melanoma. Single-cell immune repertoire profiling of serial peripheral blood sampling revealed substantial in vivo proliferation and expansion of a stem cell memory population in the endogenous T cell therapy product that achieved a >79% predominance of total circulating T cells by 3 weeks post-infusion in this non-lymphodepleted recipient. Although the patient’s disease ultimately progressed, these findings demonstrate safety and proof of concept for an IL-7 treatment regimen for expansion of adoptively transferred T cells in vivo and induced memory differentiation in a heavily pretreated patient with refractory solid malignancy.",
  "authors": [
    {
      "affiliations": [
        "Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Casey Bermack"
    },
    {
      "affiliations": [
        "Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Shailbala Singh"
    },
    {
      "affiliations": [
        "Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Guangsheng Pei"
    },
    {
      "affiliations": [
        "Departments of Medicine & Ophthalmology, University of Colorado, Aurora, Colorado, USA"
      ],
      "name": "Sapna P Patel"
    },
    {
      "affiliations": [
        "Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA",
        "Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Linghua Wang"
    },
    {
      "affiliations": [
        "Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA",
        "Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA",
        "Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Cassian Yee"
    }
  ],
  "title": "First-in-human use of recombinant IL-7 to potentiate antigen-specific T cell therapy: a single patient case study",
  "uid": "39501487-5dab-532f-a987-f3483a572ef7"
}