{
  "abstract": "γδ T cells are unconventional lymphocytes that bridge innate and adaptive immunity by combining recognition of stress-induced ligands independently of classical major histocompatibility complex molecules with the capacity to undergo clonal expansion and long-term adaptation. Their unusual ability to detect malignant transformation using semi-invariant T-cell receptors, butyrophilin recognition and natural killer-like receptors positions them as powerful effector cells in tumors that evade classical immune escape mechanisms. Furthermore, distinct γδ subsets have distinct phenotyping and specific tissue-residencies, which could be leveraged to modulate immunological responses. We evaluate engineered therapies and different experimental platforms for studying γδ T cell biology. We conclude that next-generation cancer treatments should strategically integrate γδ T cells into synthetic immunology, individualized modeling, and combinatorial regimes.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology Immunology and Allergology, Inselspital University Hospital, University of Bern, Bern, Switzerland",
        "Department for BioMedical Research, University of Bern, Bern, Switzerland",
        "Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland"
      ],
      "name": "Arnau Solé Casaramona"
    },
    {
      "affiliations": [
        "Department of Rheumatology Immunology and Allergology, Inselspital University Hospital, University of Bern, Bern, Switzerland",
        "Department for BioMedical Research, University of Bern, Bern, Switzerland",
        "Nuffield Department of Medicine, The Henry Welcome Building for Molecular Physiology, The Jenner Institute, University of Oxford, Oxford, England, UK"
      ],
      "name": "Martin F Bachmann"
    },
    {
      "affiliations": [
        "Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA"
      ],
      "name": "Eva Sevick-Muraca"
    },
    {
      "affiliations": [
        "Department of Rheumatology Immunology and Allergology, Inselspital University Hospital, University of Bern, Bern, Switzerland",
        "Department for BioMedical Research, University of Bern, Bern, Switzerland",
        "DeepVax GmbH, Zürich, Switzerland"
      ],
      "name": "Mona O Mohsen"
    }
  ],
  "title": "γδ T cells at the interface of innate and adaptive immunity in cancer",
  "uid": "845234d3-32b1-5628-bc14-ca5533ab8510"
}