{
  "abstract": "This research analyzes the global landscape of clinical trials focusing on therapies targeting the Nectin cell adhesion molecule 4 (Nectin-4) across various malignancies, using data from the Trialtrove database. Analysis of 136 interventional trials reveals a rapidly expanding field dominated by antibody-drug conjugates, particularly in urothelial carcinoma, with significant activity in combination regimens and diverse therapeutic modalities under exploration. These findings emphasize the substantial translational potential of Nectin-4 and highlight key trends shaping its future clinical development.",
  "authors": [
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Lei Li"
    },
    {
      "affiliations": [
        "Department of Hernia and Abdominal Wall Surgery, Peking University People’s Hospital, Beijing, China"
      ],
      "name": "Fei Ren"
    },
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Zhuo Liu"
    },
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Xiaojun Tian"
    },
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Hongxian Zhang"
    },
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Guoliang Wang"
    },
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Shudong Zhang"
    },
    {
      "affiliations": [
        "Department of Urology, Peking University Third Hospital, Beijing, China"
      ],
      "name": "Lulin Ma"
    }
  ],
  "title": "Clinical application prospects of Nectin-4 in pan-cancer: an analysis based on the Trialtrove database",
  "uid": "355a98ba-d4c2-5153-8761-21d99170a00a"
}