{
  "abstract": "Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, offering durable responses and prolonged survival. However, these therapies also present unique challenges, particularly with the onset of immune-related adverse events (irAEs), which can manifest during treatment either acutely and/or become chronic or emerge long after treatment cessation. Delayed, chronic, and re-emergent irAEs often require tailored survivorship care, including coordination across multiple disciplines focused on oncology, specialty care, and primary care. Despite the increased usage of ICIs, there is limited longitudinal data guiding the surveillance, diagnosis, attribution, and management of irAEs after ICI treatment. To address these gaps, the Society for Immunotherapy of Cancer convened an Expert Panel to deliberate best practices and identify research opportunities for improving post-treatment care. This paper outlines these expert insights into irAE surveillance, coordination and continuity across care transitions and settings, and clinical management strategies. The paper also underscores the importance of clinicians’ understanding of irAE onset patterns, multidisciplinary coordination, and the urgent need in the field for the development of a comprehensive irAE registry. By addressing these critical gaps, the oncology community can better support the growing population of ICI-treated cancer survivors, ensuring improved quality of life and care outcomes.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine, Division of Cancer Survivorship and Screening, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA",
        "Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Tessa F Flores"
    },
    {
      "affiliations": [
        "Office of Cancer Survivorship, National Cancer Institute Division of Cancer Control and Population Sciences, Bethesda, Maryland, USA"
      ],
      "name": "Emily S Tonorezos"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Hematology-Oncology, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA"
      ],
      "name": "Shailender Bhatia"
    },
    {
      "affiliations": [
        "Department of Oncology, Johns Hopkins Medicine Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA"
      ],
      "name": "Julie R Brahmer"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Laura C Cappelli"
    },
    {
      "affiliations": [
        "ImmunoOncology Branch, Developmental Therapy Program, National Cancer Institute Division of Cancer Treatment and Diagnosis, Bethesda, Maryland, USA"
      ],
      "name": "Monica Cooper"
    },
    {
      "affiliations": [
        "Smilow Cancer Hospital at Yale-New Haven, Yale Cancer Center, New Haven, Connecticut, USA"
      ],
      "name": "Marianne Davies"
    },
    {
      "affiliations": [
        "AIM at Melanoma, Sacramento, California, USA"
      ],
      "name": "Samantha Guild"
    },
    {
      "affiliations": [
        "Hartford HealthCare Cancer Institute, Hartford, Connecticut, USA"
      ],
      "name": "Krishna Gunturu"
    },
    {
      "affiliations": [
        "Netherlands Cancer Institute, Amsterdam, The Netherlands",
        "Leiden University Medical Center, Leiden, The Netherlands",
        "Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"
      ],
      "name": "John B A G Haanen"
    },
    {
      "affiliations": [
        "Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"
      ],
      "name": "Douglas B Johnson"
    },
    {
      "affiliations": [
        "Department of Medicine, Dermatology Division, NYU Grossman Long Island School of Medicine, Mineola, New York, USA"
      ],
      "name": "Mario E Lacouture"
    },
    {
      "affiliations": [
        "EACRI, Providence Cancer Institute, Portland, Oregon, USA"
      ],
      "name": "Rom Leidner"
    },
    {
      "affiliations": [
        "Outcomes Research Branch, National Cancer Institute Healthcare Delivery Research Program, Rockville, Maryland, USA"
      ],
      "name": "Sandra Mitchell"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut, USA"
      ],
      "name": "Dennis G Moledina"
    },
    {
      "affiliations": [
        "Section of Cardio-Oncology and Immunology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA"
      ],
      "name": "Javid Moslehi"
    },
    {
      "affiliations": [
        "Department of Oncology, Beaumont Hospital, Dublin, Leinster, Ireland",
        "RCSI University of Medicine and Health Sciences, Dublin, Leinster, Ireland"
      ],
      "name": "Jarushka Naidoo"
    },
    {
      "affiliations": [
        "Department of Medicine, LCIT center, Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"
      ],
      "name": "Michel Obeid"
    },
    {
      "affiliations": [
        "Melanoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA",
        "Department of Medicine, Weill Cornell Medical College, New York, New York, USA"
      ],
      "name": "Michael Postow"
    },
    {
      "affiliations": [
        "Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA"
      ],
      "name": "Igor Puzanov"
    },
    {
      "affiliations": [
        "Cancer Screening and Survivorship, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA"
      ],
      "name": "Mary E Reid"
    },
    {
      "affiliations": [
        "Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA",
        "Department of Neurology, Weill Cornell Medical College, New York, New York, USA"
      ],
      "name": "Bianca D Santomasso"
    },
    {
      "affiliations": [
        "Department of Dermatology and Comprehensive Cancer Cancer Center (Westdeutsches Tumorzentrum), University Hospital Essen, Essen, Germany",
        "National Center for Tumor Diseases (NCT-West), Essen, Germany",
        "Research Alliance Ruhr, Research Center One Health, University of Duisburg-Essen, Essen, Germany"
      ],
      "name": "Dirk Schadendorf"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA"
      ],
      "name": "Ann W Silk"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA"
      ],
      "name": "Ryan J Sullivan"
    },
    {
      "affiliations": [
        "Center for Health Information Partnerships, Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"
      ],
      "name": "Theresa Walunas"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Yinghong Wang"
    },
    {
      "affiliations": [
        "Department of Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy",
        "Università degli studi di Napoli Federico II, Napoli, Italy"
      ],
      "name": "Paolo A Ascierto"
    },
    {
      "affiliations": [
        "Section of Oncology, Dartmouth Health, Lebanon, New Hampshire, USA"
      ],
      "name": "Marc S Ernstoff"
    }
  ],
  "title": "Where is the data? Delayed and chronic irAE surveillance and management after cessation of ICIs: expert insights from SITC on survivorship care and the need for long-term data",
  "uid": "5da94918-fc0e-56d3-b06d-04ac48ec1c57"
}