{
  "abstract": "Background ICIs can cause a wide range of toxicities; however, limited data exists on NSIGC secondary to ICIs. Herein, we assembled the first international cohort of patients with cancer who developed NSIGC following ICI therapy.Methods We retrospectively collected data from 19 institutions worldwide on patients with cancer who received ICIs (alone or in combination with other drugs) between 2015-2025 and subsequently developed biopsy-confirmed NSIGC. The chi-squared goodness of fit test was used to analyze the association between different ICI regimens and NSIGC.Results The study included 141 patients with biopsy-confirmed NSIGC post-ICI. Of these, 58.9% (n=83) were male and 83.7% (n=118) were Caucasians. Median age at cancer diagnosis was 61 years. The top three cancers in the cohort were melanoma (51.8%; n=73), non-small cell lung cancer (16.3%; n=23), and renal cell carcinoma (6.4%; n=9). Our result showed a significant difference between expected and observed NSIGC frequencies across different ICI regimens (X2= 83.043, df=5, p < 0.0001)( table 1).Median time to NSIGC diagnosis post-ICI initiation was 7 months (range: 3.9-21.7 months). Of 141 patients, 53.9% (n=76) were diagnosed after treatment completion. Among these 76 patients, 59.4% (n=45) were diagnosed within 6 months, 14.5% (n=11) between 6-12 months, 9.2% (n=7) between 1-2 years, and 17.1% (n=13) were diagnosed after 2 years of treatment completion. The remaining 46.1% (n=65) were diagnosed during treatment. Among these, 41.5% (n=27) required permanent treatment discontinuation due to NSIGC and 4.6% (n=3) were re-challenged. Additionally, 40.4% (n=57) discontinued ICI therapy for other reasons, most commonly toxicity (47.4%; n=27) and disease progression (35.1%; n=20).There were 111 other immune-related adverse events reported in 80 patients, with colitis/diarrheas (n=21) and arthritis (n=19) being the most common. NSIGC was symptomatic in 28.4% (n=40), with 80% (n=32) achieving symptom resolution. The most commonly involved systems were skin/subcutaneous tissue (57.5%; n=23), followed by pulmonary system (32.5%; n=23). Steroid treatment for NSIGC was administered in 19.9% (n=28), with a median duration of 1.9 months. The overall response rate for the study population was 64.4%, and disease control rate was 77.3%.Conclusions To the best of our knowledge, this is the largest dataset to date demonstrating NSIGC as a rare side effect of ICIs. NSIGC frequently occurs after therapy completion but can also lead to ICI discontinuation. Biopsy confirmation is critical to prevent misdiagnosis, and further research is required to elucidate biology, risk factors, and implications for ICI continuation or rechallenge to optimize patient outcomes.Ethics Approval The IRB has reviewed the research study and determined that it meets the criteria for exemption from IRB review due to its retrospective design and minimal or no risk to patients. Name of the IRB: The University of Oklahoma Institutional Review Board for the Protection of Human Subjects ID: 17498 This study meets the criteria for a waiver of informed consent and is approved to be conducted without obtaining consent.Abstract 1037 Table 1NSIGC frequencies across different ICI regimens",
  "authors": [
    {
      "affiliations": [
        "The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"
      ],
      "name": "Ayesha Aijaz"
    },
    {
      "affiliations": [
        "University of Oklahoma, Oklahoma City, OK, USA"
      ],
      "name": "Arifa Bibi"
    },
    {
      "affiliations": [
        "Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"
      ],
      "name": "Unaiza Zaman"
    },
    {
      "affiliations": [
        "Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"
      ],
      "name": "Aqsa Ashraf"
    },
    {
      "affiliations": [
        "Sheba Medical Center, Ramat Gan, Tel Aviv District, Israel"
      ],
      "name": "Jair Bar"
    },
    {
      "affiliations": [
        "Jusidman Cancer Center, Sheba Medical Center, Ramat Gan, Tel Aviv District, Israel"
      ],
      "name": "Rachel Moskovitz Cohen"
    },
    {
      "affiliations": [
        "Jusidman Cancer Center, Sheba Medical Center, Ramat Gan, Tel Aviv District, Israel"
      ],
      "name": "Damien Urban"
    },
    {
      "affiliations": [
        "Jusidman Cancer Center, Sheba Medical Center, Ramat Gan, Tel Aviv District, Israel"
      ],
      "name": "Iddo Vardi"
    },
    {
      "affiliations": [
        "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
      ],
      "name": "Hira Tanwir"
    },
    {
      "affiliations": [
        "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
      ],
      "name": "Noha Abdel-Wahab"
    },
    {
      "affiliations": [
        "Baylor College of Medicine, Houston, TX, USA"
      ],
      "name": "Mohamed Nuh"
    },
    {
      "affiliations": [
        "University Hospital Frankfurt, Frankfurt, Geramny, Germany"
      ],
      "name": "Maximilian J Rost"
    },
    {
      "affiliations": [
        "Goethe University Frankfurt, University Hospital, Frankfurt, Germany"
      ],
      "name": "Fabian Acker"
    },
    {
      "affiliations": [
        "Goethe University Frankfurt, University Hospital, Frankfurt, Germany"
      ],
      "name": "Johannes Kleemann"
    },
    {
      "affiliations": [
        "The Ohio State Wexner Medical Center, Columbus, OH, USA"
      ],
      "name": "Hannah Smith"
    },
    {
      "affiliations": [
        "The Ohio State University, Columbus, OH, USA"
      ],
      "name": "Dwight H Owen"
    },
    {
      "affiliations": [
        "The Ohio State University WMC, Columbus, OH, USA"
      ],
      "name": "Kevin Ho"
    },
    {
      "affiliations": [
        "Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Marc Machaalani"
    },
    {
      "affiliations": [
        "Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Razane El Hajj Chehade"
    },
    {
      "affiliations": [
        "Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Toni K Choueiri"
    },
    {
      "affiliations": [
        "Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA"
      ],
      "name": "Alicia H Darwin"
    },
    {
      "affiliations": [
        "Stanford University, Cleveland, OH, USA"
      ],
      "name": "Pauline Funchain"
    },
    {
      "affiliations": [
        "Cancer Centre at Guy’s, Guy’s and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "Alfred Chung Pui So"
    },
    {
      "affiliations": [
        "Guy’s and St Thomas’ Hospitals NHS Trust, London, London, UK"
      ],
      "name": "Eleni Karapanagiotou"
    },
    {
      "affiliations": [
        "Cancer Centre at Guy’s, Guy’s and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "George Santis"
    },
    {
      "affiliations": [
        "Massachusetts General Hospital, Boston, MA, USA"
      ],
      "name": "Maysa Vilbert"
    },
    {
      "affiliations": [
        "Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA"
      ],
      "name": "Ross D Merkin"
    },
    {
      "affiliations": [
        "Massachusetts General Hospital, Boston, MA, USA"
      ],
      "name": "Kerry L Reynolds"
    },
    {
      "affiliations": [
        "Vanderbilt University School of Medicine, Nashville, TN, USA"
      ],
      "name": "Roma A Kankaria"
    },
    {
      "affiliations": [
        "Vanderbilt University Medical Center, Nashville, TN, USA"
      ],
      "name": "Douglas B Johnson"
    },
    {
      "affiliations": [
        "University of Washington, Seattle, WA, USA"
      ],
      "name": "Hans Vitzthum von Eckstaedt"
    },
    {
      "affiliations": [
        "University of Washington, Bellevue, WA, USA"
      ],
      "name": "Namrata Singh"
    },
    {
      "affiliations": [
        "Cancer Clinical Trials and Research Unit, Beaumont RCSI Cancer Centre, Dublin, Ireland"
      ],
      "name": "Maggie Louise O’Connor"
    },
    {
      "affiliations": [
        "Cancer Clinical Trials and Research Unit, Beaumont RCSI Cancer Centre, Dublin, Ireland"
      ],
      "name": "David O’Reilly"
    },
    {
      "affiliations": [
        "MedStar Washington Hospital Center, Washington, DC, USA"
      ],
      "name": "Nilansh Kataria"
    },
    {
      "affiliations": [
        "Medstar Georgetown, Washington, DC, USA"
      ],
      "name": "Muskan Agarwal"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Madrid, Spain"
      ],
      "name": "Javier Baena"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Madrid, Spain"
      ],
      "name": "Pedro Daniel Benavides Mañas"
    },
    {
      "affiliations": [
        "Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy"
      ],
      "name": "Fabrizio Citarella"
    },
    {
      "affiliations": [
        "IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) ‘Dino Amadori’, Meldola, Italy"
      ],
      "name": "Francesco De Rosa"
    },
    {
      "affiliations": [
        "IRCCS Ospedale Policlinico San Martino, Genova, Italy"
      ],
      "name": "Francesco Spagnolo"
    },
    {
      "affiliations": [
        "Medical University of Gda&nacute",
        "sk, Gda&nacute",
        "sk, Poland"
      ],
      "name": "Bartosz Kamil Sobocki"
    },
    {
      "affiliations": [
        "Medical University of Gda&nacute",
        "sk, Gda&nacute",
        "sk, Poland"
      ],
      "name": "Bartlomiej Tomasik"
    },
    {
      "affiliations": [
        "University Hospital LMU, LMU Munich, Munich, Germany"
      ],
      "name": "Lisa Arnold"
    },
    {
      "affiliations": [
        "University Hospital LMU, LMU Munich, Munich, Germany"
      ],
      "name": "Lucie Heinzerling"
    },
    {
      "affiliations": [
        "Henry Ford Health, Detroit, MI, USA"
      ],
      "name": "Shahm Raslan"
    },
    {
      "affiliations": [
        "Henry Ford Health, Detroit, MI, USA"
      ],
      "name": "Fawzi Abu Rous"
    },
    {
      "affiliations": [
        "University of Oklahoma, Oklahoma City, OK, USA"
      ],
      "name": "Sagal Pannu"
    },
    {
      "affiliations": [
        "Stephenson Cancer Center, Oklahoma University, Oklahoma City, OK, USA"
      ],
      "name": "Abdul Rafeh Naqash"
    }
  ],
  "title": "1037 Non-infectious sarcoid-like inflammatory granulomatous conditions (NSIGC) associated with Immune checkpoint inhibitors (ICIs) for cancer: updated results from the international ICARUS consortium",
  "uid": "8d517424-7d5b-5c90-9fce-fecc54b8ff90"
}