{
  "abstract": "Background With nearly one-third of patients with advanced non-small cell lung cancer (NSCLC) and PD-L1 Tumor Proportion Score≥50% surviving beyond 5 years following first-line pembrolizumab, long-term outcomes challenge traditional paradigms of cancer prognostication. The emergence of non-cancer-related factors and time-dependent trends underscores the need for advanced analytical frameworks to unravel their complex interplay.Methods We analyzed the Pembro-real 5Y registry, a global real-world dataset of 1050 patients treated across 61 institutions in 14 countries with a long-term follow-up and a large panel of baseline variables. Two complementary approaches were employed: ridge regression, chosen for its ability to address multicollinearity while retaining interpretability, and not another imputation method (NAIM), a transformer-based artificial intelligence model designed to handle missing data without imputation. Endpoints included risk of death at 6, 12, 24, 60 months and 5-year survival.Results The ridge regression model achieved a c-statistic of 0.66 (95% CI: 0.59 to 0.72) for the risk of death and an area under the curve (AUC) of 0.72 (95% CI: 0.65 to 0.78) for 5-year survival, identifying Eastern Cooperative Oncology Group Performance Status (ECOG-PS)≥2, increasing age, and metastatic burden as primary risk factors. However, wide CIs for some predictors highlighted statistical instability. NAIM demonstrated robust handling of missing data, with a c-index of 62.98±2.11 for risk of death and an AUC of 60.52±3.71 for 5-year survival. The comprehensive SHapley Additive exPlanations analysis revealed dynamic, time-dependent patterns, with early mortality dominated by acute factors (eg, ECOG-PS, steroids) and long-term outcomes increasingly influenced by systemic health markers (eg, absence of hypertension, increasing body mass index). Unexpected insights included the protective role of dyslipidemia (but not statins) and the nuanced impact of smoking status, reflecting evolving disease dynamics and host-tumor interplay.Conclusions Our integrative framework illuminates the complexity of long-term outcomes in patients with NSCLC treated with pembrolizumab, uncovering dynamic, non-linear prognostication trends. This analysis provides insights into patient trajectories, emphasizing the need for holistic, long-term management strategies.",
  "authors": [
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy",
        "Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy",
        "Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK"
      ],
      "name": "Alessio Cortellini"
    },
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy",
        "Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Valentina Santo"
    },
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy",
        "Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK"
      ],
      "name": "Leonardo Brunetti"
    },
    {
      "affiliations": [
        "Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Edoardo Garbo"
    },
    {
      "affiliations": [
        "Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK",
        "Translational Medicine Department, University of Eastern Piedmont, Novara, Italy"
      ],
      "name": "David J Pinato"
    },
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy"
      ],
      "name": "Giulia La Cava"
    },
    {
      "affiliations": [
        "Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland",
        "RCSI University of Health Sciences, Dublin, Ireland",
        "Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA"
      ],
      "name": "Jarushka Naidoo"
    },
    {
      "affiliations": [
        "Oncology Center, Hospital Sírio-Libanês, São Paulo, SP, Brazil"
      ],
      "name": "Artur Katz"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA"
      ],
      "name": "Monica Loza"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA"
      ],
      "name": "Joel W Neal"
    },
    {
      "affiliations": [
        "Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy"
      ],
      "name": "Carlo Genova"
    },
    {
      "affiliations": [
        "Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA"
      ],
      "name": "Scott Gettinger"
    },
    {
      "affiliations": [
        "Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA"
      ],
      "name": "So Yeon Kim"
    },
    {
      "affiliations": [
        "Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA"
      ],
      "name": "Ritujith Jayakrishnan"
    },
    {
      "affiliations": [
        "Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA"
      ],
      "name": "Talal El Zarif"
    },
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy"
      ],
      "name": "Marco Russano"
    },
    {
      "affiliations": [
        "Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Federica Pecci"
    },
    {
      "affiliations": [
        "Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Alessandro Di Federico"
    },
    {
      "affiliations": [
        "Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA"
      ],
      "name": "Joao V Alessi"
    },
    {
      "affiliations": [
        "Medical Thoracic Oncology Unit, IRCCS Istituto Tumori \"Giovanni Paolo II\", Bari, Italy"
      ],
      "name": "Michele Montrone"
    },
    {
      "affiliations": [
        "Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA",
        "Pelotonia Institute for Immuno-Oncology, OSUCCC – James, The Ohio State University, Columbus, OH, USA"
      ],
      "name": "Dwight H Owen"
    },
    {
      "affiliations": [
        "Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy",
        "Operative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy"
      ],
      "name": "Sara Ramella"
    },
    {
      "affiliations": [
        "Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy"
      ],
      "name": "Diego Signorelli"
    },
    {
      "affiliations": [
        "Division of Hematology/Oncology/Stem cell transplant, Rush University Medical Center, Chicago, IL, USA"
      ],
      "name": "Mary Jo Fidler"
    },
    {
      "affiliations": [
        "Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA"
      ],
      "name": "Mingjia Li"
    },
    {
      "affiliations": [
        "Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy"
      ],
      "name": "Andrea Camerini"
    },
    {
      "affiliations": [
        "Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA"
      ],
      "name": "Balazs Halmos"
    },
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy",
        "Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy"
      ],
      "name": "Bruno Vincenzi"
    },
    {
      "affiliations": [
        "Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy"
      ],
      "name": "Giulio Metro"
    },
    {
      "affiliations": [
        "Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy"
      ],
      "name": "Francesco Passiglia"
    },
    {
      "affiliations": [
        "Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA"
      ],
      "name": "Sai Yendamuri"
    },
    {
      "affiliations": [
        "SC Oncologia Medica e Traslazionale, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy"
      ],
      "name": "Annalisa Guida"
    },
    {
      "affiliations": [
        "Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy"
      ],
      "name": "Michele Ghidini"
    },
    {
      "affiliations": [
        "Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK"
      ],
      "name": "Antonio D’Alessio"
    },
    {
      "affiliations": [
        "Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, Portsmouth, UK"
      ],
      "name": "Giuseppe L Banna"
    },
    {
      "affiliations": [
        "Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK"
      ],
      "name": "Claudia A M Fulgenzi"
    },
    {
      "affiliations": [
        "Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK"
      ],
      "name": "Salvatore Grisanti"
    },
    {
      "affiliations": [
        "Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"
      ],
      "name": "Francesco Grossi"
    },
    {
      "affiliations": [
        "Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy"
      ],
      "name": "Armida D’Incecco"
    },
    {
      "affiliations": [
        "Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany"
      ],
      "name": "Eleni Josephides"
    },
    {
      "affiliations": [
        "Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK"
      ],
      "name": "Mieke Van Hemelrijck"
    },
    {
      "affiliations": [
        "Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy"
      ],
      "name": "Alessandro Russo"
    },
    {
      "affiliations": [
        "Department of Oncology, Careggi University Hospital, Florence, Italy"
      ],
      "name": "Alain Gelibter"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK"
      ],
      "name": "Gianpaolo Spinelli"
    },
    {
      "affiliations": [
        "Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland"
      ],
      "name": "Monica Verrico"
    },
    {
      "affiliations": [
        "Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland"
      ],
      "name": "Bartłomiej Tomasik"
    },
    {
      "affiliations": [
        "Medical Oncology Unit, Sant’Andrea Hospital, Roma, Italy"
      ],
      "name": "Raffaele Giusti"
    },
    {
      "affiliations": [
        "Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK"
      ],
      "name": "Kirsty Balachandran"
    },
    {
      "affiliations": [
        "Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy",
        "Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy"
      ],
      "name": "Emilio Bria"
    },
    {
      "affiliations": [
        "Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany"
      ],
      "name": "Martin Sebastian"
    },
    {
      "affiliations": [
        "Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany"
      ],
      "name": "Maximilian Rost"
    },
    {
      "affiliations": [
        "The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK"
      ],
      "name": "Martin Forster"
    },
    {
      "affiliations": [
        "The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK"
      ],
      "name": "Uma Mukherjee"
    },
    {
      "affiliations": [
        "Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy"
      ],
      "name": "Lorenza Landi"
    },
    {
      "affiliations": [
        "Department of Oncology, Careggi University Hospital, Florence, Italy"
      ],
      "name": "Francesca Mazzoni"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK"
      ],
      "name": "Avinash Aujayeb"
    },
    {
      "affiliations": [
        "Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland"
      ],
      "name": "Manuel Dupont"
    },
    {
      "affiliations": [
        "Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland"
      ],
      "name": "Alessandra Curioni-Fontecedro"
    },
    {
      "affiliations": [
        "UOC Oncologia, AST Pesaro Urbino, Pesaro, Italy"
      ],
      "name": "Rita Chiari"
    },
    {
      "affiliations": [
        "Thoracic Medical Oncology, Istituto Nazionale Tumori, IRCCS \"Fondazione G. Pascale\", Naples, Italy"
      ],
      "name": "Vincenzo Sforza"
    },
    {
      "affiliations": [
        "Department of Medicine and Surgery, University of Parma, Parma, Italy",
        "Medical Oncology Unit, University Hospital of Parma, Parma, Italy"
      ],
      "name": "Marcello Tiseo"
    },
    {
      "affiliations": [
        "Clinique Générale Beaulieu, Geneva, Switzerland"
      ],
      "name": "Alex Friedlaender"
    },
    {
      "affiliations": [
        "Oncology Service, University Hospital of Geneva, Geneva, Switzerland"
      ],
      "name": "Alfredo Addeo"
    },
    {
      "affiliations": [
        "Medical Oncology, Ospedale Santa Maria Goretti, Latina, Lazio, Italy"
      ],
      "name": "Federica Zoratto"
    },
    {
      "affiliations": [
        "Department of Innovative Technologies in Medicine & Dentistry, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy"
      ],
      "name": "Michele De Tursi"
    },
    {
      "affiliations": [
        "Fortrea Inc, Durham, North Carolina, USA"
      ],
      "name": "Luca Cantini"
    },
    {
      "affiliations": [
        "Oncologia Toracica - Lung Unit, Ospedale P. Pederzoli, Peschiera del Garda, Italy"
      ],
      "name": "Elisa Roca"
    },
    {
      "affiliations": [
        "4th Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece"
      ],
      "name": "Giannis Mountzios"
    },
    {
      "affiliations": [
        "Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy"
      ],
      "name": "Danilo Rocco"
    },
    {
      "affiliations": [
        "Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy"
      ],
      "name": "Luigi Della Gravara"
    },
    {
      "affiliations": [
        "Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA"
      ],
      "name": "Sukumar Kalvapudi"
    },
    {
      "affiliations": [
        "Medical Oncology Unit, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy"
      ],
      "name": "Alessandro Inno"
    },
    {
      "affiliations": [
        "Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy"
      ],
      "name": "Paolo Bironzo"
    },
    {
      "affiliations": [
        "Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany"
      ],
      "name": "Rafael Di Marco Barros"
    },
    {
      "affiliations": [
        "Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland"
      ],
      "name": "David O’Reilly"
    },
    {
      "affiliations": [
        "Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland"
      ],
      "name": "Orla Fitzpatrick"
    },
    {
      "affiliations": [
        "Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany"
      ],
      "name": "Eleni Karapanagiotou"
    },
    {
      "affiliations": [
        "Service de Pneumologie, Centre Hospitalier Intercommunal, Creteil, France"
      ],
      "name": "Isabelle Monnet"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Madrid, Spain"
      ],
      "name": "Javier Baena"
    },
    {
      "affiliations": [
        "Department of Oncology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy"
      ],
      "name": "Marianna Macerelli"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain"
      ],
      "name": "Aida Piedra"
    },
    {
      "affiliations": [
        "Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"
      ],
      "name": "Francesco Agustoni"
    },
    {
      "affiliations": [
        "Division of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori di Monza, Monza, Italy",
        "Department of Clinical Medicine, University of Milano-Bicocca, Milano, Italy"
      ],
      "name": "Diego Luigi Cortinovis"
    },
    {
      "affiliations": [
        "Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy",
        "Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy"
      ],
      "name": "Giuseppe Tonini"
    },
    {
      "affiliations": [
        "Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy"
      ],
      "name": "Gabriele Minuti"
    },
    {
      "affiliations": [
        "Oncology Unit, Santa Maria delle Croci Hospital Ravenna, AUSL della Romagna, Ravenna, Italy"
      ],
      "name": "Chiara Bennati"
    },
    {
      "affiliations": [
        "Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain",
        "Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain"
      ],
      "name": "Laura Mezquita"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Hospital Clinic, Barcelona, Spain"
      ],
      "name": "Teresa Gorría"
    },
    {
      "affiliations": [
        "Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"
      ],
      "name": "Alberto Servetto"
    },
    {
      "affiliations": [
        "Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
      ],
      "name": "Teresa Beninato"
    },
    {
      "affiliations": [
        "Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
      ],
      "name": "Giuseppe Lo Russo"
    },
    {
      "affiliations": [
        "Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy",
        "Department of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy"
      ],
      "name": "Arsela Prelaj"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy"
      ],
      "name": "Andrea De Giglio"
    },
    {
      "affiliations": [
        "Medical Oncology Department, Hospital Universitario Infanta Leonor, Madrid, Spain"
      ],
      "name": "Jacobo Rogado"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain"
      ],
      "name": "Laura Moliner"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain"
      ],
      "name": "Ernest Nadal"
    },
    {
      "affiliations": [
        "Translational Medicine Department, University of Eastern Piedmont, Novara, Italy"
      ],
      "name": "Federica Biello"
    },
    {
      "affiliations": [
        "Division of Pneumology, Cliniques Universitaires St-Luc, UCLouvain, Brussels, Belgium"
      ],
      "name": "Frank Aboubakar Nana"
    },
    {
      "affiliations": [
        "Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands"
      ],
      "name": "Anne-Marie Dingemans"
    },
    {
      "affiliations": [
        "Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands"
      ],
      "name": "Joachim G J V Aerts"
    },
    {
      "affiliations": [
        "Università Vita-Salute San Raffaele, Milano, Italy",
        "Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy"
      ],
      "name": "Roberto Ferrara"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan",
        "Department of Internal Medicine, Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA, USA"
      ],
      "name": "Taher Abu Hejleh"
    },
    {
      "affiliations": [
        "Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan"
      ],
      "name": "Kazuki Takada"
    },
    {
      "affiliations": [
        "Medical Oncology/TSET Phase 1 Program, The University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA"
      ],
      "name": "Abdul Rafeh Naqash"
    },
    {
      "affiliations": [
        "Thoracic Oncology Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA"
      ],
      "name": "Marina Chiara Garassino"
    },
    {
      "affiliations": [
        "Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland"
      ],
      "name": "Solange Peters"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA"
      ],
      "name": "Heather A Wakelee"
    },
    {
      "affiliations": [
        "Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA"
      ],
      "name": "Amin H Nassar"
    },
    {
      "affiliations": [
        "Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Biagio Ricciuti"
    },
    {
      "affiliations": [
        "Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy",
        "Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden"
      ],
      "name": "Paolo Soda"
    },
    {
      "affiliations": [
        "Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy"
      ],
      "name": "Camillo Maria Caruso"
    },
    {
      "affiliations": [
        "Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy"
      ],
      "name": "Valerio Guarrasi"
    }
  ],
  "title": "Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry",
  "uid": "40d90a0e-e42a-51d1-9fb4-1b6c9d66ba7d"
}