{
  "abstract": "Background Behaviours across a 24-hour day, including physical activity, sedentary time and sleep, are disrupted following cancer and contribute to cancer-related outcomes. This study describes the day-to-day 24-hour behaviour profiles of individuals with and without cancer, considering time since diagnosis and cancer types.Methods Seven days of accelerometer data from the UK Biobank (M±SD age=62.3±7.9 years; 56.4% female) were derived from machine learning models to assess the 24-hour behaviours in individuals with cancer (n=10 152; M±SDyears since diagnosis=7.4±6.1 years) compared with healthy (free of diseases) individuals (n=13 722). Diagnoses were identified using the International Classification of Disease codes within cancer registries. Bayesian compositional data analysis compared profiles between individuals with and without cancer, across time since diagnosis (<1 year, 1–5 years, >5 years) and 14 cancer types.Results The least physically active profiles were observed for individuals within 1 year following cancer diagnosis and in cancers with poor prognoses. Compared with healthy individuals, those within 1 year following cancer diagnosis had 40 min/day less physical activity (light plus moderate-to-vigorous intensities), compensated by 40 min/day more inactive time (sedentary plus sleep periods). Differences also varied across cancer types, ranging from 22–75 min/day less physical activity and 22–75 min/day more inactive time, between individuals with cancers and healthy individuals. Cancers with poorer prognoses (eg, lung, gastrointestinal tract) had the least optimal profiles, whereas cancers with better prognoses (eg, prostate, skin) showed profiles closer to healthy individuals.Conclusion The 24-hour behaviour profiles differed by cancer history, prognosis and type. Supporting a healthy balance of behaviours, that can feasibly be achieved within a 24-hour day, should be considered for cancer survivors, particularly in the year after diagnosis and in poor prognosis cancers.",
  "authors": [
    {
      "affiliations": [
        "School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia",
        "Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Flora Le"
    },
    {
      "affiliations": [
        "Alliance for Research in Exercise, Nutrition and Activity, School of Allied Health & Human Performance, Adelaide University, Adelaide, South Australia, Australia"
      ],
      "name": "Dorothea Dumuid"
    },
    {
      "affiliations": [
        "School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia",
        "Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Olivia D’Elia"
    },
    {
      "affiliations": [
        "School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia",
        "Institute of Medical Biometry and Statistics, University of Freiburg, Freiburg, Germany"
      ],
      "name": "Alexander Haussmann"
    },
    {
      "affiliations": [
        "Mackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia",
        "School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Emmanuel Stamatakis"
    },
    {
      "affiliations": [
        "Department of Kinesiology, University of Texas at Arlington, Arlington, Virginia, USA"
      ],
      "name": "Yue Liao"
    },
    {
      "affiliations": [
        "Nuffield Department of Population Health, University of Oxford, Oxford, UK"
      ],
      "name": "Aiden Doherty"
    },
    {
      "affiliations": [
        "School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia",
        "Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Joshua F Wiley"
    }
  ],
  "title": "24-hour physical activity, sedentary behaviour and sleep profiles in individuals with cancer: a UK Biobank cohort study",
  "uid": "aacf8cba-fb57-5399-8e0a-119a56939aa6"
}