{
  "abstract": "Background Allostatic load (AL) is the physiological burden of stress, and it is suggested to be a mediator between socioeconomic position and health. The aim of this article was to study life-course trajectories in levels of AL by employing data collected over three decades (1994–2019) to compare sex and socioeconomic groups in the adult Norwegian population.Methods Harmonised data from the following Norwegian health studies were used: the Trøndelag Health Study, the Tromsø Study, the Age 40 Program and CONOR. In total, 264 824 participants aged 30–79 years contributed with 346 312 health examinations. A combined AL score was calculated as the number of biomarkers in the worst quartile among the following eight variables: systolic blood pressure, diastolic blood pressure, resting heart rate, triglycerides, total cholesterol, high-density lipoprotein cholesterol, body mass index and waist-hip ratio. High-sensitivity C reactive protein and glycated haemoglobin were included in sensitivity analyses for a subset of participants. Life-course trajectories were analysed by using a linear mixed model. A shared-parameter model was employed to evaluate attrition caused by death.Results Participants with primary education had higher AL compared with secondary and tertiary educated people in all age groups. Men had higher AL than women throughout the life-course. Overall, AL increased with age but levelled off at higher ages among women and decreased at higher ages among men.Conclusions We found significant socioeconomic inequalities and sex differences in AL throughout the life-course. This highlights a potential for improvement in public health by effective treatment and public health measures to reduce AL inequities.",
  "authors": [
    {
      "affiliations": [
        "HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"
      ],
      "name": "Siri Høivik Storeng"
    },
    {
      "affiliations": [
        "HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway",
        "Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway"
      ],
      "name": "Erik Reidar Sund"
    },
    {
      "affiliations": [
        "Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway"
      ],
      "name": "Knut Eirik Dalene"
    },
    {
      "affiliations": [
        "Method Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway",
        "Cancer Registry of Norway, Department of Registration, Folkehelseinstituttet, Oslo, Norway"
      ],
      "name": "Simon Lergenmuller"
    },
    {
      "affiliations": [
        "Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway"
      ],
      "name": "Inger Ariansen"
    },
    {
      "affiliations": [
        "HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway",
        "Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway"
      ],
      "name": "Steinar Krokstad"
    }
  ],
  "title": "Socioeconomic inequalities in allostatic load in a large Norwegian cohort study: the NCDNOR project",
  "uid": "c900019b-43de-5069-bf45-e3db668a6fe1"
}