{
  "abstract": "Background Alcohol consumption is a modifiable dementia risk factor, but differences in prognosis, symptoms, and likelihood of care home residence between alcohol-related and other dementias remain unclear.Methods We conducted a retrospective cohort study using the Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics and Office for National Statistics mortality data. Overall, 212,951 adults aged ≥40 years with dementia and recorded alcohol use were included. Dementia was identified from primary care and hospital diagnostic codes (Read and ICD-10). Alcohol-related dementia was defined as clinically recognised alcohol-related cognitive impairment or dementia with ≥50 units/week or an alcohol use disorder (AUD) code. Non-alcohol-related dementia was defined as dementia with <7 units/week and no AUD code. Neuropsychiatric symptoms and psychotropic prescriptions were identified using clinical codes. Adjusted logistic and Cox models (age, sex, smoking, ethnicity, deprivation) estimated odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals.Results 16,541 (7.7%) had alcohol-related dementia and 99,701 (46.8%) had non-alcohol-related dementia. The alcohol-related group was diagnosed about five years earlier (median 77 years, robust SD 9.6) than the non-alcohol group (median 82 years, robust SD 7.4) and died younger (median 81.8 years, robust SD 8.6 vs 86.5 years, robust SD 6.8). They had higher odds of neuropsychiatric symptoms (OR = 1.39, 95% CI 1.33–1.45), particularly psychosis (OR = 1.89, 95% CI 1.75–2.02) and challenging behaviour (OR = 1.41, 95% CI 1.33–1.51), and greater antidepressant and anxiolytic/hypnotic use. In adjusted survival models, the alcohol-related group showed longer post-diagnosis survival (HR = 0.83, 95% CI 0.80–0.86) but younger age at death, indicating earlier onset and a distinct clinical trajectory.Conclusion Alcohol-related dementia presents a distinct clinical profile compared to non-alcohol-related dementia, characterized by earlier onset, greater odds of neuropsychiatric symptoms—particularly psychosis and behavioural disturbances. These findings highlight the significant long-term neuropsychiatric and social burdens associated with alcohol-related dementia.",
  "authors": [
    {
      "affiliations": [
        "Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK"
      ],
      "name": "Nasri Fatih"
    },
    {
      "affiliations": [
        "Department of Epidemiology and Population Health, London School of Hygiene, London School of Hygiene Tropical Medicine, London, UK"
      ],
      "name": "Krishnan Bhaskaran"
    },
    {
      "affiliations": [
        "Department of Psychiatry, University of Oxford, Oxford, UK"
      ],
      "name": "Klaus Ebmeier"
    },
    {
      "affiliations": [
        "Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK"
      ],
      "name": "Thomas Nichols"
    },
    {
      "affiliations": [
        "Department of Psychiatry, Yale University School of Medicine, Yale University, Connecticut, USA"
      ],
      "name": "Joel Gelernter"
    },
    {
      "affiliations": [
        "Department of Statistics, University of Oxford, Oxford, UK"
      ],
      "name": "Maria Christodoulou"
    },
    {
      "affiliations": [
        "Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK"
      ],
      "name": "Anya Topiwala"
    }
  ],
  "title": "P06-1 Clinical profile and outcomes of alcohol-related dementia: a comparative cohort study",
  "uid": "acb144a6-638f-5f61-9361-3f928365ad8f"
}