{
  "abstract": "Background Gastroschisis is the most common congenital abdominal wall defect. It has favourable mortality outcomes with most individuals surviving into adulthood, yet less is known about ongoing morbidity risks. This study aimed to examine morbidity outcomes particularly hospitalisations and surgeries in early childhood in children born with gastroschisis.Methods A population-based data linkage study of eight European congenital anomaly registries using their data on children with gastroschisis born between 1995 and 2014 and electronic health records. Five registries (Finland, Spain, Wales and two in Italy) included data from live-born children without congenital anomalies born during the same period (reference children). A descriptive analysis of hospitalisations, length of stay, and surgical data was conducted.Results We included data on 1028 children born with gastroschisis. 54.5% of these were born preterm (95% confidence intervals [CI] 51.4-57.6). Hospitalisations were highest in the first year of life across all registries but were also three times higher than the reference population at ages 1 to <5 years (pooled incidence rate ratio 2.9, 95% CI 1.9-4.5). Length of stay in hospital at ages 1 to <5 years was shorter than during the first year of life. Only 2.8% (95% CI 1.4-4.7) of hospitalisations in this age group lasted 10 days or more, compared with 89.8% (95% CI 86.8-92.4) in the first year of life, although results in the older children were variable across registries.Conclusion Children with gastroschisis experience high morbidity that continues beyond the first year of life and their initial surgery. Future research should focus on understanding morbidity risks according to the complexity of the anomaly. Research on the causes of hospitalisations after the first year of life will help provide information to plan future care for these children.",
  "authors": [
    {
      "affiliations": [
        "School of Medicine, Cardiff, UK"
      ],
      "name": "Shivparakash Arun"
    },
    {
      "affiliations": [
        "Congenital Anomaly Register and Information Service, Public Health Wales, 2 Capital Quarter, Tyndall Street, Cardiff, and Singleton Hospital, Swansea, UK"
      ],
      "name": "Samantha Fisher"
    },
    {
      "affiliations": [
        "Neonatal Intensive Care Unit, Pediatric Section, Department of Medical Sciences, Ferrara University, Ferrara, Italy"
      ],
      "name": "Elisa Ballardini"
    },
    {
      "affiliations": [
        "Rare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain"
      ],
      "name": "Clara Cavero Carbonell"
    },
    {
      "affiliations": [
        "Unit of Epidemiology of Rare diseases and Congenital anomalies, Institute of Clinical Physiology, National Research Council, Pisa, Italy"
      ],
      "name": "Alessio Coi"
    },
    {
      "affiliations": [
        "Congenital Anomaly Register and Information Service, Public Health Wales, 2 Capital Quarter, Tyndall Street, Cardiff, and Singleton Hospital, Swansea, UK"
      ],
      "name": "Llion Davies"
    },
    {
      "affiliations": [
        "Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Kolding, Denmark"
      ],
      "name": "Ester Garne"
    },
    {
      "affiliations": [
        "THL Finnish Institute for Health and Welfare, Department of Data and Analytics, Helsinki, Finland, Region Stockholm, Academic Primary Health Care Centre & Department of Molecular Medicine and Surgery,"
      ],
      "name": "Mika Gissler"
    },
    {
      "affiliations": [
        "Congenital Anomaly Register and Information Service, Public Health Wales, 2 Capital Quarter, Tyndall Street, Cardiff, and Singleton Hospital, Swansea, UK"
      ],
      "name": "David Tucker"
    },
    {
      "affiliations": [
        "School of Medicine, Cardiff, UK"
      ],
      "name": "Lisa Hurt"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Health & Life Science, Swansea University, Swansea, UK"
      ],
      "name": "Sue Jordan"
    },
    {
      "affiliations": [
        "Institute of Nursing and Health Research, Ulster University, Belfast, UK"
      ],
      "name": "Maria Loane"
    },
    {
      "affiliations": [
        "City St George’s University of London, London, UK"
      ],
      "name": "Joan K Morris"
    },
    {
      "affiliations": [
        "Health and Life Sciences, Swansea University, Wales, UK"
      ],
      "name": "Ieuan Scanlon"
    },
    {
      "affiliations": [
        "NIHR Great Ormond Street Hospital Biomedical Research Centre, UCL GOS Institute of Child Health, London, UK"
      ],
      "name": "Joachim Tan"
    },
    {
      "affiliations": [
        "Mathematica Policy Research, Princeton, NJ, USA"
      ],
      "name": "Daniel Thayer"
    }
  ],
  "title": "P12-8 Morbidity in children with gastroschisis: a population-based data linkage study",
  "uid": "4c6c2149-15e3-55c7-998d-1037687df86e"
}