{
  "abstract": "Epidemiology relies on the accurate evaluation of external validity, yet the dissemination of clinical evidence remains structurally skewed by geography. We identify a ‘Large-N Paradox’, where non-Western clinical registries with massive sample sizes and high representativeness are systematically filtered into specialty journals, while smaller Western cohorts frequently appear in top-tier general medical journals.",
  "authors": [
    {
      "affiliations": [
        "Department of Clinical Information Applied Sciences, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Bunkyo, Tokyo, Japan",
        "Department of Public Health, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Bunkyo, Tokyo, Japan"
      ],
      "name": "Tomoki Kawahara"
    },
    {
      "affiliations": [
        "Department of Public Health, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Bunkyo, Tokyo, Japan"
      ],
      "name": "Yuto Maeda"
    },
    {
      "affiliations": [
        "Department of Public Health, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Bunkyo, Tokyo, Japan"
      ],
      "name": "Shuhei Terada"
    },
    {
      "affiliations": [
        "Department of Public Health, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Bunkyo, Tokyo, Japan"
      ],
      "name": "Takeo Fujiwara"
    }
  ],
  "title": "‘Large-N’ Paradox: geographic bias in clinical evidence",
  "uid": "6b8232a7-a223-5693-94cd-4653ea947b9f"
}