{
  "abstract": "Background Evidence on the short-term association between particulate matter with an aerodynamic diameter of ≤1 µm (PM 1) and mortality from chronic obstructive pulmonary disease (COPD) is scarce. We aimed to explore the potential effects of PM1 on COPD mortality.Methods We conducted a province-wide time-stratified case-crossover study in 13 cities of Jiangsu province, China, from 2015 to 2019. Daily mortality data were collected and PM 1 at the individual level was estimated using a gridded dataset (10 km × 10 km) linked to personal residential addresses. The effects of PM1 on COPD mortality were evaluated using conditional logistic regression. We also investigated the exposure–response relations and potential effect modifiers.Results A total of 255 043 COPD deaths were included in data analyses. Each 10 μg/m 3 increase in PM1 was associated with increased mortality risk of 3.32% (2.67%–3.97%) for COPD, 3.75% (2.30%–5.22%) for chronic bronchitis, 3.25% (1.09%–5.45%) for emphysema and 3.35% (2.56%–4.15%) for acute exacerbation of COPD (AECOPD), respectively. Natural cubic splines analysis revealed linear relationships for PM1 and COPD mortality. Particulate matter with an aerodynamic diameter of ≤2.5 µm (PM2.5) had slightly weaker effects on COPD mortality than PM1. Population attributable fractions for PM1-related mortality from COPD, chronic bronchitis, emphysema and AECOPD were 8.86%, 8.84%, 8.25% and 8.86%, respectively.Conclusions This study provides new evidence of an association between short-term exposure to PM 1 and COPD mortality. Our findings suggest a predominant role of PM1 within PM2.5 and emphasise the need for targeted strategies to reduce PM1 concentrations.",
  "authors": [
    {
      "affiliations": [
        "Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Wenfeng Lu"
    },
    {
      "affiliations": [
        "Department of Environment and Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China"
      ],
      "name": "Hong Sun"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Ruijun Xu"
    },
    {
      "affiliations": [
        "Department of Atmospheric and Oceanic Science, University of Maryland, College Park, Maryland, USA"
      ],
      "name": "Jing Wei"
    },
    {
      "affiliations": [
        "National Meteorological Information Center, China Meteorological Administration, Beijing, China"
      ],
      "name": "Chunxiang Shi"
    },
    {
      "affiliations": [
        "Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Chenghui Zhong"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Yuewei Liu"
    },
    {
      "affiliations": [
        "Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Yun Zhou"
    }
  ],
  "title": "Ambient PM1 on COPD mortality: insights from a population-based study",
  "uid": "0ee263bb-d13d-5d3b-b91e-a448d11b2f4c"
}