{
  "abstract": "Background Adverse drug reactions (ADR) and adverse drug events (ADE) can be a preventable source of harm to older patients. hospital admissions in older adults due to ADRs has been estimated to be 8.7%. Many studies have investigated the prevalence and risk factors for ADRs and ADEs in older populations but a systematic review of studies investigating the short and longer-term health outcomes associated with experiencing an ADR or ADE is not available. The objective was to investigate short and long-term health outcomes associated with experiencing ADRs and ADEs in older populations.Methods A systematic search of Ovid Medline, Ebsco Cinahl, and Embase (2013–2024) identified studies examining ADR/ADE prevalence and associated health outcomes (hospitalisation, outpatient use, GP visits, quality of life, depression, anxiety, falls, frailty, and functional impairments) in adults aged ≥65. Risk of bias was assessed using JBI critical appraisal tools.Results In total, 15 studies were included, with some studies measuring several outcomes. Sample sizes ranged from 112 to 34,593,000 older adults. Older patients that experienced an ADR/ADE had an increased risk of; hospitalisation (8 studies), mortality (7 studies), prolonged length of hospital stay (LOS) (4 studies), disability (2 studies) and overall survival (1 study). ADRs accounted for a notable percentage of hospitalisations among older adults, with varying estimates ranging from 3.3% to 16.6%. Mortality due to ADRs in the elderly varies widely across studies, with rates ranging from 4.3% to 21.6%, highlighting the lack of consistent research in this area. ADRs also contributed significantly to extended hospital stays, with studies showing a 17% to 2.8-fold increase in hospital stay length for those affected by ADRs. It was found that studies were determined to be of minimal and good quality.Conclusion It is important to develop interventions and support services that mitigate the healthcare burden of ADR/ADEs in older populations. Increased health literacy around medications, alongside medication reviews may enable patients to consider medications as a possible cause of adverse symptoms and help to limit the impact of ADE/ADR on short- and longer-term outcomes. However, this review calls for targeted research and clinical efforts to mitigate the impact of ADRs on older adults, particularly in the areas of deprescribing and improving health outcomes, but also more research of good quality within the area of health outcomes after an ADR/ADE.",
  "authors": [
    {
      "affiliations": [
        "School of Population Health, Royal College of Surgeons in Ireland"
      ],
      "name": "Juliane Frydenlund"
    },
    {
      "affiliations": [
        "School of Population Health, Royal College of Surgeons in Ireland"
      ],
      "name": "Mark Stroughair"
    },
    {
      "affiliations": [
        "School of Population Health, Royal College of Surgeons in Ireland"
      ],
      "name": "Malaika Peter"
    },
    {
      "affiliations": [
        "School of Population Health, Royal College of Surgeons in Ireland"
      ],
      "name": "Samantha Trevaskis"
    },
    {
      "affiliations": [
        "Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands"
      ],
      "name": "Daniala Weir"
    },
    {
      "affiliations": [
        "Department of Clinical Pharmacy and Toxicology, Maastricht University, The Netherlands"
      ],
      "name": "Fatma Karapinar"
    },
    {
      "affiliations": [
        "School of Population Health, Royal College of Surgeons in Ireland"
      ],
      "name": "Caitriona Cahir"
    }
  ],
  "title": "P48 Short- and long-term health outcomes following an adverse drug reaction or an adverse drug event in older populations: a systematic review",
  "uid": "40cda567-1441-569b-b1dc-1561654b98f8"
}