{
  "abstract": "Myeloid neoplasms (MN) with MECOM rearrangements can present either myelodysplastic neoplasms (MDS) or acute myeloid leukaemia (AML), both associated with dismal prognosis. The 2022 WHO classification now defines these as ‘AML with MECOM rearrangements’ regardless of blast counts due to similarly poor outcomes.1 Classic MECOM rearrangements include inv(3)(q21q26.2) and t(3;3)(q21;q26), referred to as inv(3)/t(3;3), while non-classic subtypes involve 3q26.2/MECOM with other partners.2 Both forms result in MECOM overexpression promoting leukemogenesis. Chemotherapy outcomes are poor, with median overall survival rates of 12.9 months in MDS and 7.9 months in AML.3 This study aimed to determine the frequency, clinical characteristics and treatment outcomes of this subtype among Thai patients from the national MN registry.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand",
        "Center of Excellence in Translational Hematology, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Chantana Polprasert"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Khon Kaen University, Khon Kaen, Thailand"
      ],
      "name": "Chinadol Wanitpongpun"
    },
    {
      "affiliations": [
        "Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand",
        "Center of Excellence in Translational Hematology, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Chantiya Chanswangphuwana"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"
      ],
      "name": "Thanawat Rattanathammethee"
    },
    {
      "affiliations": [
        "Department of Medicine, Mahidol University, Ramathibodi Hospital, Bangkok, Thailand"
      ],
      "name": "Pimjai Niparuck"
    },
    {
      "affiliations": [
        "Precision Pathology of Neoplasia Research Unit, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Narittee Suksawai"
    },
    {
      "affiliations": [
        "Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand",
        "Center of Excellence in Translational Hematology, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Ponthip Mekchay"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand"
      ],
      "name": "Weerapat Owattanapanich"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand"
      ],
      "name": "Smith Kungwankiattichai"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"
      ],
      "name": "Ekarat Rattarittamrong"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"
      ],
      "name": "Adisak Tantiworawit"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Thammasat University, Bangkok, Thailand"
      ],
      "name": "Wasithep Limvorapitak"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Thammasat University, Bangkok, Thailand"
      ],
      "name": "Supawee Saengboon"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Prince of Songkla University, Songkla, Thailand"
      ],
      "name": "Jakrawadee Julamanee"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Prince of Songkla University, Songkla, Thailand"
      ],
      "name": "Pirun Saelue"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand"
      ],
      "name": "Kannadit Prayongratana"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand"
      ],
      "name": "Ekapun Karoopongse"
    },
    {
      "affiliations": [
        "Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand",
        "Center of Excellence in Translational Hematology, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Ponlapat Rojnuckarin"
    },
    {
      "affiliations": [
        "Department of Medicine, Mahidol University, Ramathibodi Hospital, Bangkok, Thailand"
      ],
      "name": "Suporn Chuncharunee"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand"
      ],
      "name": "Chantrapa Sriswasdi"
    }
  ],
  "title": "Clinical characteristics and outcomes of myeloid neoplasms with MECOM rearrangements",
  "uid": "1ede4d40-2902-5ab4-90ca-18a9c782ca18"
}