{
  "abstract": "Aims High-grade extremity soft tissue sarcomas (eSTS) are rare, heterogeneous malignancies with a high metastatic potential. Prognostic assessment remains challenging due to wide variation in outcomes. Current risk stratification relies on traditional risk factors like age, histology, grade and tumour size, which are embedded in risk classification scores. Recent advances in the fields of biochemistry, pathology and molecular genetics may offer additional prognostic insights, although their clinical utility remains unclear. This scoping review aimed to map the evidence on clinically available biomarkers with potential prognostic value in adults with high-grade eSTS.Methods A broad search of MEDLINE and Embase identified 9739 records, of which 74 studies met the eligibility criteria.Results Overall, available evidence is retrospective and heterogeneous. Potential biomarkers were identified across three domains: biochemical, pathological and molecular. Although several biomarkers showed potential prognostic value, few studies assessed their independence from key confounders.Conclusions Standardised validation, with adjustment for established prognostic variables, is needed before these biomarkers can be integrated into risk prediction models for routine clinical practice.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical Oncology, UZ Gent, Ghent, Belgium",
        "Department of Internal Medicine and Paediatrics, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium"
      ],
      "name": "Kiara Peirens"
    },
    {
      "affiliations": [
        "Department of Pathology, UZ Gent, Ghent, Belgium",
        "Department of Diagnostic Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium"
      ],
      "name": "David Creytens"
    },
    {
      "affiliations": [
        "Department of Pathology, UZ Gent, Ghent, Belgium",
        "Department of Diagnostic Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium"
      ],
      "name": "Fleur Cordier"
    },
    {
      "affiliations": [
        "Department of Radiology and Medical Imaging, UZ Gent, Ghent, Belgium",
        "Departments of Human Structure and Repair and Diagnostic Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium"
      ],
      "name": "Thomas Van Den Berghe"
    },
    {
      "affiliations": [
        "Departments of Human Structure and Repair and Diagnostic Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium"
      ],
      "name": "Jens De Temmerman"
    },
    {
      "affiliations": [
        "Department of Medical Oncology, UZ Gent, Ghent, Belgium",
        "Department of Internal Medicine and Paediatrics, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium"
      ],
      "name": "Lore Lapeire"
    }
  ],
  "title": "Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review",
  "uid": "c766362c-2bb6-5a73-a78b-b5147c891014"
}