{
  "abstract": "Primary lung tumours are rare in paediatric patients. Mucoepidermoid carcinoma (MEC), typically low-grade and diagnostically straightforward, is the second most common tumour of the bronchus after carcinoid tumours. However, rare MEC may show divergent differentiation, be misdiagnosed as low-grade adenocarcinoma, not otherwise classified, and pose clinical challenges, especially when mastermind-like protein 2 (MAML2) gene arrangement is negative by fluorescence in situ hybridisation (FISH). Here, we report an MAML2 FISH-negative low-grade bronchial tumour in a juvenile patient that demonstrates both mucoepidermoid and acinar differentiation based on morphology and immunophenotype. Next-generation sequencing identified a CREB regulated transcription coactivator 3 (CRTC3::MAML2) fusion gene, located upstream of traditional translocation points and potentially undetectable by currently available FISH probes. This tumour appears to be a novel presentation of a bronchial tumour with dual mucoepidermoid and acinar differentiation, first described as mucoacinar carcinoma—a newly proposed subtype of MEC, originally described in the major salivary gland.",
  "authors": [
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Yu Zhang"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Rui Liang"
    },
    {
      "affiliations": [
        "The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Gabriel Christopher Purnell"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Lei Yan"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Alia Nazarullah"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Sarah Hackman"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Courtney Thomas"
    },
    {
      "affiliations": [
        "Department of Cardiothoracic Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Aaron M Abarbanell"
    },
    {
      "affiliations": [
        "Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Aaron Sugalski"
    },
    {
      "affiliations": [
        "Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Jeffrey L Foster"
    },
    {
      "affiliations": [
        "Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Linda P Thomas"
    },
    {
      "affiliations": [
        "Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Phillip Ong"
    },
    {
      "affiliations": [
        "Department of Cardiothoracic Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Daniel DeArmond"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Marjorie Parker David"
    },
    {
      "affiliations": [
        "Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Faqian Li"
    }
  ],
  "title": "Bronchial mucoacinar carcinoma: a newly proposed subtype of mucoepidermoid carcinoma in the bronchus",
  "uid": "8bfc899c-adda-53db-b5fc-08993d7f0d45"
}