{
  "abstract": "In this issue of the Journal of Clinical Pathology, Dr. Nishikori discusses the challenges in distinguishing between the idiopathic plasmacytic lymphadenopathy (IPL) type of idiopathic multicentric Castleman disease (iMCD) and IgG4-related lymphadenopathy.1 They highlight the significant overlap in clinical, immunological and serological features between the two diseases. Notably, no differences in serum IgG4 levels were observed. However, iMCD-IPL patients tend to be older and exhibit higher serum IgG, IgA, IgM, IgE and acute phase reactants such as C-reactive protein (CRP) while showing lower haemoglobin and albumin levels. However, the combination of serum IgG4/IgG ratio (<19%), serum IgG (>5381 mg/dL) and elevated CRP (>6 mg/dL) may aid in the distinction between iMCD-IPL and IgG4-related disease (IgG4-RD) (table 1).",
  "authors": [
    {
      "affiliations": [
        "Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA"
      ],
      "name": "Vikram Deshpande"
    },
    {
      "affiliations": [
        "Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Judith Ferry"
    }
  ],
  "title": "Diagnostic dilemmas in idiopathic multicentric Castlemans disease idiopathic plasmacytic lymphadenopathy (IPL) type and IgG4-related lymphadenopathy: challenges in recognition and distinction, especially in western pathology",
  "uid": "4ef62347-54f3-5b8c-a753-1a5c1f0907cb"
}