{
  "abstract": "Hypereosinophilic syndrome (HES) is a heterogeneous disorder characterised by persistent, abnormal eosinophil elevation in blood and tissues, with multisystem involvement. Cardiac manifestations are frequent in HES and significantly worsen prognosis. Recent evidence establishes a direct link between HES and myocardial infarction (MI), demonstrating that HES induces MI primarily via non-atherosclerotic mechanisms. Critically, HES-related MI is fundamentally distinct from atherosclerotic MI in pathogenesis, diagnosis and management. This paradigm shift redefines diagnostic frameworks for cardiovascular disease and provides targeted strategies for non-atherosclerotic MI. This review synthesises current knowledge on HES-associated MI, emphasising its unique epidemiology, pathophysiology, evidence-based diagnostic criteria and mechanism-specific therapies. Future research priorities are discussed to advance clinical translation.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China"
      ],
      "name": "Jiao Li"
    },
    {
      "affiliations": [
        "Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China"
      ],
      "name": "Wenjun Jia"
    },
    {
      "affiliations": [
        "Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China"
      ],
      "name": "Qi Li"
    },
    {
      "affiliations": [
        "Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China"
      ],
      "name": "Yue Liu"
    },
    {
      "affiliations": [
        "Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China"
      ],
      "name": "Zhenying Zhou"
    },
    {
      "affiliations": [
        "Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China"
      ],
      "name": "Liping Wei"
    }
  ],
  "title": "Non-atherosclerotic myocardial infarction in hypereosinophilic syndrome: emerging insights and therapeutic approaches",
  "uid": "e5205256-cde0-5128-a01a-37e822f4a84c"
}