{
  "abstract": "Background Diastolic dysfunction is one of the pre-clinical indicators of heart failure with preserved ejection fraction (HFpEF), characterised by left ventricular (LV) stiffness without impairing systolic function. Type 2 diabetes mellitus (T2DM) may be a driver of HFpEF, as it is linked to a higher risk of mortality and hospitalisation. HFpEF accounts for half of heart failure cases, however, effective treatment options remain limited.Aim ‘This study aimed to investigate the association between diastolic dysfunction and type 2 diabetes mellitus (T2DM) in an adult population from Liverpool, accounting for age and sex.’Methods Data was collected retrospectively from 493 patient records about their diastolic function status, diabetes status, age and sex. Echocardiographic parameters were used to assess and grade diastolic function according to the 2016 American Society of Echocardiography (ASE) and European Association of Cardiovascular Imaging (EACVI) recommendations, while HbA1c levels were used to assess diabetic status.Results Diastolic dysfunction was more prevalent in type 2 diabetics (71.42%) than non-diabetic patients (43.98%) (p <0.05). The odds ratio of developing diastolic dysfunction was 2.636 times higher in diabetics, with 2.56 times greater odds of a higher dysfunction grade (p <0.001). Age ≥65 years was associated with 4.65 times higher odds of having diastolic dysfunction, with no significant difference between genders.Conclusion This study found a statistically significant association between type 2 diabetes, advancing age, and diastolic dysfunction. Due to the metabolic alterations that are associated with diabetes and the pathophysiology of HFpEF, there is great potential for the use of lifestyle changes and antidiabetic therapies as cardioprotective agents aimed at reducing heart failure morbidity and mortality. Since diabetes is found to be an independent factor for increasing the risk of HFpEF, we suggest it should be included in the H2FpEF score.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiology, Royal Liverpool University Hospital, Liverpool, United Kingdom"
      ],
      "name": "Mohammad Adeeb Abbara"
    },
    {
      "affiliations": [
        "Department of Cardiology, Royal Liverpool University Hospital, Liverpool, United Kingdom"
      ],
      "name": "Laila Wali"
    },
    {
      "affiliations": [
        "Department of Cardiology, Royal Liverpool University Hospital, Liverpool, United Kingdom"
      ],
      "name": "Sowmya Ekhelikar"
    },
    {
      "affiliations": [
        "Department of Cardiology, Royal Liverpool University Hospital, Liverpool, United Kingdom"
      ],
      "name": "Khaled Albouaini"
    },
    {
      "affiliations": [
        "Department of Cardiology, Royal Liverpool University Hospital, Liverpool, United Kingdom"
      ],
      "name": "Scott Murray"
    }
  ],
  "title": "179 Diastolic dysfunction and diabetes: the DIADAD study – a retrospective cohort study from Liverpool",
  "uid": "feae1df4-70b7-5fbd-928a-8c4fe84a2012"
}