{
  "abstract": "Background Long-term beta-blocker therapy has historically been recommended following acute myocardial infarction (AMI) to reduce mortality and recurrent ischemic events. In the contemporary era of routine percutaneous coronary intervention and optimized guideline-directed medical therapy, a substantial proportion of patients recover with preserved left ventricular ejection fraction (LVEF), rendering the benefit of prolonged beta-blocker therapy in this population uncertain.Methods A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines. PubMed, Cochrane Library, and Google Scholar were searched. Statistical analyses were performed using RevMan version 5.4, applying a random-effects model to pool risk ratios (RRs) with 95% confidence intervals (CIs). A p-value <0.05 was considered statistically significant.Results Five RCTs, comprising 23,524 participants (11,744 receiving beta-blockers and 11,780 controls) were included. Over a mean follow-up of three years, beta-blocker therapy showed no significant effect on all-cause mortality (RR 0.98, 95% CI: 0.87–1.11) or cardiovascular mortality (RR 1.06, 95% CI: 0.83–1.36). Similarly, no significant differences were observed for secondary outcomes: major adverse cardiovascular events (MACE) (RR 0.96, 95% CI: 0.85–1.07), recurrent myocardial infarction (RR 0.89, 95% CI: 0.78–1.02), stroke (RR 1.27, 95% CI: 0.92–1.76), or hospitalizations for heart failure (RR 0.77, 95% CI: 0.56–1.05) ( figures 1 and 2).Conclusion In patients with acute myocardial infarction and preserved LVEF, long-term beta-blockers showed no reduction in mortality, recurrent MI, stroke, MACE, or HF admissions, indicating limited routine benefit. Future large-scale, rigorously designed randomized trials are warranted to clarify their role in long-term secondary prevention.Abstract 316 Figure 1Forest plots for (A) all-cause mortality, (B) MACE, and (C) recurrent MIAbstract 316 Figure 2Forest plots for (A) cardiovascular mortality, (B) stroke, and (C) hospitalizations for heart failure",
  "authors": [
    {
      "affiliations": [
        "Worcestershire Acute Hospital NHS Trust, UK"
      ],
      "name": "Mohsin Nawaz"
    },
    {
      "affiliations": [
        "Medicine Specialities, Worcestershire Acute Hospitals NHS Trust, UK"
      ],
      "name": "Tony Chandy Babu"
    },
    {
      "affiliations": [
        "CCT- Cardiology Consultant, Sheikh Shakhbout Medical City, Abu Dhabi, UAE"
      ],
      "name": "Hala Sharaf"
    },
    {
      "affiliations": [
        "Nixor College, Karachi, Pakistan"
      ],
      "name": "Haniya Mallick"
    },
    {
      "affiliations": [
        "United Arab Emirates University, Abu Dhabi, UAE"
      ],
      "name": "Omar Alzaabi"
    },
    {
      "affiliations": [
        "St. Joseph’s Healthcare Hamilton Charlton Campus, Hamilton, Ontario, Canada"
      ],
      "name": "Moaz Alowami"
    },
    {
      "affiliations": [
        "Department of Cardiology, University Hospitals Plymouth NHS Trust, UK"
      ],
      "name": "Abdul Khan"
    },
    {
      "affiliations": [
        "University of Khartoum, Sudan"
      ],
      "name": "Eman Ibrahim Elzain Hassan"
    },
    {
      "affiliations": [
        "Department of General Internal Medicine, Cumberland Infirmary, Carlisle, UK"
      ],
      "name": "Rajdeepsinh Hariharsinh Rana"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE"
      ],
      "name": "Yasmeen Maarraoui"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE"
      ],
      "name": "Mohammed Alrubaei"
    },
    {
      "affiliations": [
        "Palliative Medicine, Royal Berkshire University Hospital, Reading, UK"
      ],
      "name": "Zenab Ehsan"
    },
    {
      "affiliations": [
        "Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan"
      ],
      "name": "Eeshal Zulfiqar"
    }
  ],
  "title": "316 Long-term beta-blocker therapy after acute myocardial infarction in patients with preserved ejection fraction: a meta-analysis",
  "uid": "2db254c1-244d-5365-b23d-2975cab325ba"
}