{
  "abstract": "Introduction Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the UK, accounting for a quarter of all deaths annually. Many of these deaths can be prevented through better control of risk factors. Despite well-established evidence and treatment guidelines, cholesterol levels remain sub-optimally managed in many high-risk patients. The British Heart Foundation’s (BHF) Bridging Hearts report found that cardiovascular outcomes are strongly influenced by ethnicity, sex and socioeconomic deprivation due to differences in health care access, risk factor management and care delivery pathways. Without standardisation, treatment intensification and follow up can vary due to clinician biases, patient literacy and system pressures. Pharmacist led lipid clinics offer an opportunity to reduce variation in treatment delivery through structured education and continuity of care. This study evaluates whether a data driven pharmacist led pathway achieves equitable lipid optimisation for secondary prevention patients across a West London Borough.Methods Patients with established atherosclerotic cardiovascular disease and residual elevated lipid levels were identified using ICD-10 and SNOMED coding and referred to a pharmacist led review. Information regarding ethnicity, sex, age and index of multiple deprivation (IMD) were automatically extracted. The review involved a structured consultation with the pharmacist, intensification of medication if required and follow up at set agreed intervals. Outcomes were assessed using a pre-post design. Primary outcomes included LDL-C reduction and attainment of LDL-C targets. Secondary outcomes assessed equity of treatment goals by comparing outcomes across sex, ethnicity and IMD quintiles.Results Among 204 secondary prevention patients, 65% were from ethnically diverse backgrounds and 71% were male. The mean baseline LDL-C for the patients was 3.39 mmol/L and 13% were not actively receiving lipid lowering therapy ( table 1). Attendance following referral by IMD quintile was 7.4% (most deprived), 34%, 33%, 13% and 12% (least deprived) (figure 1A). Following the intervention, mean LDL-C decreased to 1.97 mmol/L (41.8% reduction) with 70.6% achieving LDL-C targets. Absolute LDL-C reduction and target attainment were comparable with no significant differences observed across sex, ethnicity or IMD quintile (figure 1B). Among patients receiving high intensity statins, 66.3% met their target LDL-C levels and 89.4% of patients on high intensity statin combined with ezetimibe achieved targets. Patients who decided for non-pharmacological therapy also demonstrated a 46% reduction in LDL-C (n=46).Conclusion These results provide evidence that a pharmacist led lipid optimisation pathway achieved significant LDL-C reduction and target attainment among secondary patients without introducing or amplifying disparities across sex, ethnicity or deprivation. This suggests that consistent, proactive delivery of care can preserve equity that commonly diverges once patients enter care pathways. In addition, we found a meaningful reduction in LDL-C even in patients who decided for non-pharmacological therapies, which suggests that through behavioural reinforcements, structured education and continuity of care, this may reinforce the importance of adherence and lifestyle modification. However, attendance from the most deprived quintile remains low, which may be explained by upstream barriers to access and highlights the need for a more integrated and targeted approach within the community to achieve truly equitable prevention. We provide a scalable framework for potential expansion into primary prevention and cardio-reno-metabolic pathways.Abstract 97 Figure 1AAbstract 97 Figure 1BAbstract 97 Table 1Baseline characteristics of the cohort attending the pharmacist-led lipid",
  "authors": [
    {
      "affiliations": [
        "James Cook University Hospital, Middlesbrough, United Kingdom"
      ],
      "name": "Joshua Xu"
    },
    {
      "affiliations": [
        "Imperial College London, National Heart and Lung Institute, London, United Kingdom",
        "Chelsea & Westminster NHS Foundation Trust, London, United Kingdom"
      ],
      "name": "Jasjit Syan"
    },
    {
      "affiliations": [
        "Chelsea & Westminster NHS Foundation Trust, London, United Kingdom"
      ],
      "name": "Hussein Alhakem"
    },
    {
      "affiliations": [
        "Chelsea & Westminster NHS Foundation Trust, London, United Kingdom"
      ],
      "name": "John Foster"
    },
    {
      "affiliations": [
        "Chelsea & Westminster NHS Foundation Trust, London, United Kingdom"
      ],
      "name": "Grant McQueen"
    },
    {
      "affiliations": [
        "Imperial College London, National Heart and Lung Institute, London, United Kingdom",
        "Chelsea & Westminster NHS Foundation Trust, London, United Kingdom"
      ],
      "name": "Sadia Khan"
    }
  ],
  "title": "97 Evaluating whether a data driven, pharmacist led pathway preserves equity in lipid management",
  "uid": "0979a690-dcd0-59f5-9769-045d65e14689"
}