{
  "abstract": "Background Real-life data is very useful for gaining a better understanding of care in practice and identifying areas for improvement. This study aimed to assess changes in the clinical characteristics, care and outcomes of patients hospitalised with acute heart failure (HF).Methods Two multicentre snapshot surveys were conducted in 2009 and 2021 following the same methodology and enrolled 1658 and 1513 patients, respectively. Clinical characteristics, hospitalisation pathways, in-hospital management and short-term outcomes during a 6-month follow-up were collected.Results While the age of patients and the proportion in each left ventricular ejection fraction (LVEF) category remained largely unchanged (76 years and 53% with reduced LVEF in the two surveys), there was a rise in the prevalence of most comorbidities. Emergency department was the predominant and increasing route for hospitalisation (64–71%), and admission to critical care units remained frequent and stable (40%). In patients with reduced LVEF, the prescription rate of ACE inhibitors, angiotensin receptor blockers or angiotensin receptor-neprilysin inhibitors (ARNis) decreased from 77.8% to 70.6%, while the use of beta-blockers and mineralocorticoid receptor antagonists increased (67.7–74.2% and 26.6–35.5%, respectively) at discharge. Mortality at 1 and 6 months declined from 8.9% to 7.6% and from 24.7% to 21.3%, respectively. This difference was also significant after matching the two cohorts (HR 0.78 (0.66–0.94)). This improvement in mortality was observed in most patients except in the most elderly and those with preserved LVEF.Conclusions A comparison of two cross-sectional surveys of acute HF, conducted 12 years apart, reveals an increasing burden of comorbidities, as well as a lack of dedicated admission pathways and a significant shortcoming in the prescription of evidence-based HF drugs on discharge. However, there has been a significant decrease in short-term mortality.Trial registration number NCT01080937 and NCT05232058.",
  "authors": [
    {
      "affiliations": [
        "Paris Cité University, Paris, France",
        "Cardiology Department, Hospital Group Saint-Louis Lariboisiere and Fernand-Widal, Paris, France"
      ],
      "name": "Damien Logeart"
    },
    {
      "affiliations": [
        "Cardiology, University Hospital Centre Poitiers, Poitiers, France"
      ],
      "name": "Benjamin Alos"
    },
    {
      "affiliations": [
        "Cardiology Department, University Hospital Centre Caen, Caen, France"
      ],
      "name": "Damien Legalloisl"
    },
    {
      "affiliations": [
        "Cardiology, University Hospital Centre Clermont-Ferrand, Clermont-Ferrand, France"
      ],
      "name": "Clerfond Guillaume"
    },
    {
      "affiliations": [
        "Cardiology Department, University Hospital Centre Reims Thoracic and Cardio-Vascular Medicine Section, Reims, France"
      ],
      "name": "Jerome Costa"
    },
    {
      "affiliations": [
        "Cardiologie, European Hospital Georges Pompidou, Paris, France"
      ],
      "name": "Etienne Puymirat"
    },
    {
      "affiliations": [
        "Cardiology Department, Departmental Hospital Centre La Roche-sur-Yon, La Roche-sur-Yon, France"
      ],
      "name": "Guillaume Turlotte"
    },
    {
      "affiliations": [
        "Cardiology Department, Chartres Hospital Center, Chartres, France"
      ],
      "name": "Christophe Thuaire"
    },
    {
      "affiliations": [
        "University Hospital Centre Bordeaux, Talence, France"
      ],
      "name": "François Picard"
    },
    {
      "affiliations": [
        "Paris Cité University, Paris, France",
        "Cardiology, Bichat - Claude-Bernard Hospital Cardiology Service, Paris, France"
      ],
      "name": "Guillaume Jondeau"
    },
    {
      "affiliations": [
        "University Hospital Centre Nantes Division 2 Thorax and Nervous System Institute, Nantes, France"
      ],
      "name": "Jean-Noel Trochu"
    },
    {
      "affiliations": [
        "Cardiology, Rennes University Hospital Pontchaillou Site, Rennes, France"
      ],
      "name": "Erwan Donal"
    },
    {
      "affiliations": [
        "Service de Cardiologie, Lille Regional and University Hospital, Lille, France"
      ],
      "name": "Pascal De Groote"
    },
    {
      "affiliations": [
        "Cardiology Department, Centre Cardiologique du Nord, Saint-Denis, France"
      ],
      "name": "Diane Bodez"
    },
    {
      "affiliations": [
        "Intensive Cardiac Care Unit, University Hospital Centre Toulouse, Toulouse, France"
      ],
      "name": "Clément Delmas"
    },
    {
      "affiliations": [
        "Cardiology Department, Centre Hospitalier Universitaire de Grenoble, Grenoble, France"
      ],
      "name": "Muriel Salvat"
    },
    {
      "affiliations": [
        "Cardiology Department, Hopitaux Universitaires Pitie Salpetriere-Charles Foix, Paris, France"
      ],
      "name": "Louise Legrand"
    },
    {
      "affiliations": [
        "Clinityx Company, Boulogne-Billancourt, France"
      ],
      "name": "Maxime Doublet"
    },
    {
      "affiliations": [
        "Cardiology, University Hospital Centre Poitiers, Poitiers, France",
        "University of Poitiers, Poitiers, France"
      ],
      "name": "Claire Bouleti"
    }
  ],
  "title": "Temporal trends in characteristics, management and prognosis of patients with acute heart failure through two repeated snapshots",
  "uid": "7f2165dd-2f00-5653-88e0-49b2a8b539b7"
}