{
  "abstract": "Background The prevalence and clinical correlates of extra-aortic vascular disease in Marfan syndrome remain incompletely defined, and current surveillance strategies primarily target the thoracic aorta.Methods We conducted a multicentre retrospective cohort study of 783 patients with Marfan syndrome across three tertiary centres, with systematic chart and imaging adjudication to define aneurysm and dissection distribution.Results Extra-aortic aneurysms were identified in 32% of patients, most commonly involving the iliac, carotid and subclavian arteries. Extra-aortic dissections occurred in 5.2%. Extra-aortic aneurysms clustered strongly with markers of advanced aortic disease, including abdominal aortic aneurysm (adjusted OR 3.48), prior aortic dissection (OR 3.39) and extra-aortic dissection (OR 4.44), as well as age >40 years and male sex. Genetic confirmation status was not associated with extra-aortic aneurysm presence.Conclusions Extra-aortic vascular involvement is common in Marfan syndrome and closely linked to advanced aortic pathology. These findings support risk-stratified vascular imaging beyond the thoracic aorta in higher-risk patients.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Hussein Abdul Nabi"
    },
    {
      "affiliations": [
        "Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Luke Arnulfo Dreher"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Hunter Vandolah"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Hend Bcharah"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "George Bcharah"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Christopher Kanaan"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Ramzi Ibrahim"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Mahmoud Abdelnabi"
    },
    {
      "affiliations": [
        "Mayo Clinc, Rochester, Minnesota, USA"
      ],
      "name": "Linnea M Baudhuin"
    },
    {
      "affiliations": [
        "Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Yuxiang Wang"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic, Rochester, New York, USA"
      ],
      "name": "Hicham Z El Masry"
    },
    {
      "affiliations": [
        "Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Chadi Ayoub"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA",
        "Department of Clinical Genomics, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Fadi E Shamoun"
    }
  ],
  "title": "Prevalence and predictors of extra-aortic aneurysms in Marfan syndrome",
  "uid": "fccbe98c-7480-5d1b-8fa3-867d0498970d"
}