{
  "abstract": "Background Myeloperoxidase (MPO), a neutrophil-derived enzyme, is associated with oxidative stress and inflammation, which contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Bioactive MPO causes vascular dysfunction and accumulation of serum uric acid (SUA). We investigated the association of plasma MPO and SUA with echocardiographic variables in a populational setting.Methods This was a cross-sectional analysis of the fourth visit of the STANISLAS cohort (N=1677 participants, age 49±14 years, 48% male), a population of initially healthy individuals. Participants were divided into four groups according to median plasma MPO and SUA levels. Adjusted linear regression models were used to assess the relationship of plasma MPO and SUA with echocardiographic markers.Results Participants with high MPO and high SUA were older, had more diabetes, a higher body mass index, lower estimated glomerular filtration rate and higher systolic blood pressure. In multivariable regression analyses, compared with patients with low MPO and low SUA, they had decreased left atrial reservoir strain (mean±SE=−1.43±0.62, p=0.022), decreased mitral annular e’ velocity (mean±SE=−0.60±0.16, p<0.001) and more impaired left ventricular systolic global longitudinal strain (mean±SE=0.50±0.23, p=0.029). In contrast, high MPO with low SUA was not associated with impaired diastolic function.Conclusions In a population setting, high MPO and SUA, indicative of high bioactive MPO, were associated with early markers of diastolic dysfunction, suggesting a potential role of the MPO pathway in the early development of HFpEF.",
  "authors": [
    {
      "affiliations": [
        "School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia",
        "Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA",
        "The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"
      ],
      "name": "Nelson Wang"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France"
      ],
      "name": "Constance Xhaard"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France"
      ],
      "name": "Guillaume Baudry"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique, INSERM 1433, CHRU de Nancy, Institut Lorrain du Coeur et des Vaisseaux, Nancy, France"
      ],
      "name": "Luca Monzo"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France"
      ],
      "name": "Erwan Bozec"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France"
      ],
      "name": "Kévin Duarte"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France",
        "Medical Specialties and Nephrology Dialysis Departments, Princess Grace Hospital and Private Hemodialysis Centre, Monaco"
      ],
      "name": "Patrick Rossignol"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France"
      ],
      "name": "Faiez Zannad"
    },
    {
      "affiliations": [
        "Division of Cardiology, Department of Medicine, Karolinska Institutet, and Heart and Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Lars Lund"
    },
    {
      "affiliations": [
        "Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France"
      ],
      "name": "Nicolas Girerd"
    }
  ],
  "title": "Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals",
  "uid": "279ebac4-dd94-5014-bcaf-7b33a1a3bcf7"
}