{
  "abstract": "Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterised by cardiac and non-cardiac physiologic disturbances, commonly underpinned by cardiometabolic abnormalities, which culminate in elevated left ventricular filling pressures and progressive symptoms of exercise intolerance. Arrhythmias, particularly atrial fibrillation (AF), are common in HFpEF and have important clinical implications. AF complicates the diagnosis and management of HFpEF. In this review, we synthesise the impact of AF on disease detection, symptom burden and prognosis and HFpEF treatment. Furthermore, we review pharmacological and interventional therapies that may mitigate the risk of AF and improve how patients with HFpEF feel, function and survive.",
  "authors": [
    {
      "affiliations": [
        "Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium",
        "Department of Cardiology, Antwerp University Hospital (UZA), Edegem, Belgium"
      ],
      "name": "Faro Verelst"
    },
    {
      "affiliations": [
        "Leeds Teaching Hospitals NHS Trust and, University of Leeds, Leeds, UK"
      ],
      "name": "Klaus K Witte"
    },
    {
      "affiliations": [
        "Keele Cardiovascular Research Group, Keele University, Keele, UK"
      ],
      "name": "Fozia Z Ahmed"
    },
    {
      "affiliations": [
        "Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA"
      ],
      "name": "Sana M Al-Khatib"
    },
    {
      "affiliations": [
        "Division of Cardiology, Department of Medicine, Dalhousie University & Queen Elisabeth II Health Sciences Center, Halifax, Nova Scotia, Canada"
      ],
      "name": "Ratika Parkash"
    },
    {
      "affiliations": [
        "Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium",
        "Department of Cardiology, Antwerp University Hospital (UZA), Edegem, Belgium"
      ],
      "name": "Andreas B Gevaert"
    },
    {
      "affiliations": [
        "Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada",
        "Population Health Research Institute, Hamilton, Ontario, Canada",
        "Baim Institute for Clinical Research, Boston, Massachusetts, USA",
        "Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada"
      ],
      "name": "Harriette G C Van Spall"
    }
  ],
  "title": "Atrial fibrillation and heart failure with preserved ejection fraction: diagnostic challenges and therapeutic opportunities",
  "uid": "94543618-f97f-54a3-aa3e-3f01e01130f4"
}