{
  "abstract": "Background Safety and efficacy of supervised exercise training (ET) remain unclear in left ventricular assist device (LVAD) patients. A systematic review with an individual participant data (IPD) meta-analysis was performed to determine: (1) safety, (2) the effects of ET on peak oxygen consumption (peakVO 2), 6 min walk distance (6MWT) and quality of life (QoL) and (3) the effects of ET on different subgroups of patients with LVAD (age, sex, body mass index (BMI), time post LVAD implantation, baseline exercise performance).Methods IPD were retrieved from all published randomised, controlled trials that compared the efficacy of ET versus standard care in LVAD patients. One-stage and two-stage (sensitivity analysis) meta-analyses were used to determine the effects of ET overall and for subgroup and ET effects interactions.Results Four trials that included 119 LVAD patients (89.1 % males; age: mean (SD), 53 (14) years; BMI: 28 (5) kg/m 2; ejection fraction: 19 (6)%) were analysed. ET was safe and improved peakVO2 (mean difference (95% CI) +1.43 (0.39 to 2.45) mL/kg/min, p=0.004), 6MWT distance (+48 (95% CI 24 to 73) m, p<0.001), QoL (+0.66 (95% CI 0.26 to 1.05) standardised units, p<0.001) more than standard care. Males, older patients, 1 year post LVAD implantation and those with lower baseline BMI and (sub)maximal exercise performance had larger benefit of ET.Conclusions ET is safe and improves (sub)maximal exercise performance and QoL in LVAD patients, and should be considered in management of LVAD.PROSPERO registration number CRD42023480119.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine in Sport and Exercise, University of Ljubljana Faculty of Sport, Ljubljana, Slovenia",
        "Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands"
      ],
      "name": "Tim Kambič"
    },
    {
      "affiliations": [
        "Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC) – Medical Heart Centre of Charité and German Heart Institute Berlin, Berlin, Germany",
        "Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany",
        "DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany"
      ],
      "name": "Anna Feuerstein"
    },
    {
      "affiliations": [
        "Department of Medical Statistics, University Medical Centre Göttingen, Göttingen, Germany",
        "DZHK (German Centre for Cardiovascular Research), Partner Site Lower Saxony, Göttingen, Germany"
      ],
      "name": "Tim Friede"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, The Alfred Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Kate Hayes"
    },
    {
      "affiliations": [
        "Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, Michingan, USA"
      ],
      "name": "Dennis J Kerrigan"
    },
    {
      "affiliations": [
        "Cardiac Rehabilitation Laboratory, Onassis Cardiac Surgery Center, Athens, Greece"
      ],
      "name": "Ioannis D Laoutaris"
    },
    {
      "affiliations": [
        "Department of Medical Statistics, University Medical Centre Göttingen, Göttingen, Germany"
      ],
      "name": "Phuc Thien Tran"
    },
    {
      "affiliations": [
        "Division of Cardiology, General Hospital, Murska Sobota, Slovenia",
        "Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"
      ],
      "name": "Mitja Lainscak"
    },
    {
      "affiliations": [
        "Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC) – Medical Heart Centre of Charité and German Heart Institute Berlin, Berlin, Germany",
        "Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany",
        "DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany"
      ],
      "name": "Frank Edelmann"
    }
  ],
  "title": "Effects of exercise training in left ventricular assist device patients: a systematic review with an individual participant data meta-analysis",
  "uid": "78b80109-5e5d-5ba3-92a3-7449ea308ed5"
}