{
  "abstract": "As transcatheter aortic valve implantation (TAVI) is increasingly used in younger and lower-risk patients, long-term valve durability has become a growing concern. Bioprosthetic valve degeneration (BVD) is multifactorial, encompassing calcific and non-calcific structural deterioration, non-structural deterioration, valve thrombosis and procedural or device-related factors. This review aims to provide a look across the spectrum of understanding BVD, presenting insights from fundamental and translational science through to the clinic to give a comprehensive overview of the mechanisms underlying BVD in TAVI valves. This review highlights the pivotal role of multimodality imaging in detection, classification and monitoring of degeneration and discusses the emerging pharmacological and engineering innovations aimed at preventing degeneration. Finally, reintervention strategies, including redo-TAV and surgical explantation, are explored with an emphasis on CT-based planning and bench-testing insights that have enhanced our understanding of BVD and inform ongoing procedural refinement. These perspectives support a proactive and tailored approach to managing transcatheter aortic valve degeneration across the patient’s lifetime.",
  "authors": [
    {
      "affiliations": [
        "Cardiovascular Translational Lab, Centre for Heart Lung Innovation & Providence Research, University of British Columbia, Vancouver, British Columbia, Canada"
      ],
      "name": "Joshua Yoon"
    },
    {
      "affiliations": [
        "Department of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"
      ],
      "name": "Quentin Liabot"
    },
    {
      "affiliations": [
        "Cardiovascular Translational Lab, Centre for Heart Lung Innovation & Providence Research, University of British Columbia, Vancouver, British Columbia, Canada"
      ],
      "name": "Colin Jamieson"
    },
    {
      "affiliations": [
        "Cardiovascular Translational Lab, Centre for Heart Lung Innovation & Providence Research, University of British Columbia, Vancouver, British Columbia, Canada"
      ],
      "name": "Brooke MacLeod"
    },
    {
      "affiliations": [
        "Cardiovascular Translational Lab, Centre for Heart Lung Innovation & Providence Research, University of British Columbia, Vancouver, British Columbia, Canada",
        "Department of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"
      ],
      "name": "David Meier"
    },
    {
      "affiliations": [
        "Cardiovascular Translational Lab, Centre for Heart Lung Innovation & Providence Research, University of British Columbia, Vancouver, British Columbia, Canada",
        "Dilawri Cardiovascular Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada",
        "Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada"
      ],
      "name": "Stephanie L Sellers"
    }
  ],
  "title": "Transcatheter aortic valve degeneration: a combined clinical and translational perspective",
  "uid": "335f2523-f265-5bf5-a4a0-d8288796a8ef"
}