{
  "abstract": "Background Elevation in serum troponin following elective percutaneous coronary intervention (PCI) is indicative of post-PCI troponin increase (pTI) and is associated with higher mortality rates. In this analysis, we sought to identify clinical and angiographic risk factors for pTI.Methods Consecutive patients undergoing elective PCI with drug-eluting stent implantation at Mount Sinai Hospital, New York, USA, between 2012 and 2022 were retrospectively analysed. Patients with elevated baseline troponin (>1× upper reference limit (URL)) and missing baseline or post-PCI troponin values were excluded. pTI was defined according to the cut-offs established by the Fourth Universal Definition of Myocardial Infarction (UDMI, ≥5× URL) and the Academic Research Consortium 2 (ARC-2) definition (≥35× URL). Predictors of pTI were evaluated through multivariable logistic regression with stepwise selection of candidate covariates.Results Of the 10 592 included patients, 16.3% had pTI by UDMI criteria and 4.4% by ARC-2 criteria. Predictors of pTI for both definitions included low-density lipoprotein cholesterol, lesion length and maximum stent diameter, while higher left ventricular ejection fraction, prior PCI and intravascular imaging use had a protective effect. Female sex, anaemia and P2Y12 inhibitor loading (as opposed to chronic therapy) predicted UDMI-defined pTI but not ARC-2-defined pTI, whereas chronic kidney disease predicted only ARC-2-defined pTI.Conclusions In conclusion, there are patient-specific angiographic and clinical risk factors that can predict pTI. These risk factors should be considered in formulating more individualised risk assessment for those undergoing elective PCI.",
  "authors": [
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Sean Gilhooley"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA",
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "Mauro Gitto"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Alessandro Spirito"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Samantha Sartori"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Angelo Oliva"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Birgit Vogel"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Prakash Krishnan"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Karim Kamaledin"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA",
        "Cardiovascular and Thoracic Department, University Hospital San Giovanni di Dio e Ruggi d’Aragona, Salerno, Italy"
      ],
      "name": "Francesca Maria Di Muro"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Pedro Moreno"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Benjamin Bay"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Joseph Sweeny"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Parasuram Melarcode Krishnamoorthy"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Annapoorna Kini"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "George D Dangas"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Samin K Sharma"
    },
    {
      "affiliations": [
        "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Roxana Mehran"
    }
  ],
  "title": "Predictors of postprocedural troponin increase in patients undergoing elective percutaneous coronary intervention",
  "uid": "b1e624e3-f6b0-5e0d-a216-2a250410252b"
}