{
  "abstract": "Background The current commissioning models of cardiac and pulmonary rehabilitation for single index conditions such as post-revascularisation, and heart failure may not be addressing the complex needs of people living with multiple long-term conditions (MLTC).Aim The overarching aim of the PERFORM research programme is to develop and evaluate a bespoke co-designed exercise and self-management rehabilitation programme (PERFORM) for people with MLTC. This presentation reports the findings of our feasibility trial.Methods A mixed methods two-group randomised controlled feasibility trial conducted across 3 UK sites. 60 adults with MLTC (defined as presence of ≥2 LTC) with at least one known to benefit from exercise therapy, were randomised 2:1 to PERFORM intervention plus usual care or usual care alone (control). The PERFORM intervention consisted of eight-weeks supervised group-based exercise rehabilitation and self-care symptom-based support. Feasibility outcomes included: trial recruitment (percentage of a target of 60 participants recruited within 4.5-months), retention (percentage of participants with complete EQ-5D data at 3-months), and intervention adherence (percentage of intervention group attending ≥60% sessions). Secondary outcome measures of health-related quality of life, exercise capacity, and symptoms were assessed at baseline and 3-month follow-up. A parallel process evaluation assessed acceptability and feasibility from perspectives of participants and intervention delivery teams.Results Target recruitment was met within the timeframe. Participants (57% female, mean age: 62±13 years, BMI: 30.8±8.0 kg/m 2) had a median of 4 LTC (most common: diabetes (41.7%), hypertension (38.3%), and asthma (36.7%)). EQ-5D outcome retention was 76.7% (46/60 participants) and intervention adherence was 72.5% (29/40 participants). Secondary outcomes within the PERFORM group showed a trend towards greater improvements at 3-months compared to the control group (table 1).Abstract O3 Table 1Secondary outcomes at baseline and 3-month follow-up PERFORM (n=40) Usual care (n=20) Baseline 3 -months Baseline 3 -months Between-group difference of change (95% CI ) EQ-5D Utility Index 0.55 (0.34) 0.60 (0.24) 0.54 (0.25) 0.55 (0.30) 0.05 (-0.07, 0.17) ISWT distance, m 294 (186) 334 (226) 404 (154) 309 (231) 65 (-5, 136) FACIT-F 27.9 (1.9) 32.3 (2.2) 26.2 (2.9) 25.3 (3.9) 3.7 (-1.0, 8.4) Dyspnoea-12 8.5 (1.5) 7.0 (1.5) 8.5 (2.1) 9.5 (2.5) -2.0 (-5.5, 1.5) PHQ-9 8.9 (7.0) 7.7 (6.1) 8.7 (6.7) 8.6 (5.4) -0.5 (-3.5, 2.5) GAD-7 6.4 (1.1) 4.8 (0.9) 5.4 (1.2) 5.0 (1.6) -0.9 (-3.7, 1.9) MoCA 24.6 (2.6) 25.4 (2.9) 25.6 (2.5) 27.2 (1.8) 0.1 (-1.3, 1.5) Conclusion Our feasibility study supports progression to our ongoing multicentre RCT across 20 UK sites to assess clinical- and cost-effectiveness of the PERFORM intervention for people living with MLTC.",
  "authors": [
    {
      "affiliations": [
        "MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK",
        "Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK"
      ],
      "name": "Rod S Taylor"
    },
    {
      "affiliations": [
        "MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK"
      ],
      "name": "Grace Dibben"
    },
    {
      "affiliations": [
        "General Practice and Primary Care, School of Health and Wellbeing, University of Glasgow, Glasgow, UK"
      ],
      "name": "Frances Mair"
    },
    {
      "affiliations": [
        "General Practice and Primary Care, School of Health and Wellbeing, University of Glasgow, Glasgow, UK"
      ],
      "name": "Bhautesh Jani"
    },
    {
      "affiliations": [
        "MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK"
      ],
      "name": "Sharon Simpson"
    },
    {
      "affiliations": [
        "Respiratory Sciences, University of Leicester, Leicester, UK"
      ],
      "name": "Sally J Singh"
    },
    {
      "affiliations": [
        "MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK",
        "Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK",
        "General Practice and Primary Care, School of Health and Wellbeing, University of Glasgow, Glasgow, UK",
        "Respiratory Sciences, University of Leicester, Leicester, UK"
      ],
      "name": "on behalf of the PERFORM collaboration"
    }
  ],
  "title": "O3 Personalised exercise-rehabilitation FOR people with multiple long-term conditions (PERFORM): a new paradigm for rehabilitation provision?",
  "uid": "10d446d7-0842-5bf2-ac38-d1335ca93af8"
}