{
  "abstract": "Background Sex differences in out-of-hospital cardiac arrest (OHCA) have been studied in adults but remain poorly explored in younger populations. We aimed to assess sex differences in OHCA across age groups to provide a comprehensive overview.Methods All OHCA occurring between May 2011 and December 2018 in Paris and its suburbs were analysed. Primary outcomes included sex differences in OHCA characteristics and survival to hospital discharge across three age groups: paediatric patients (28 days-18years), young adults (18–35 years) and older adults (≥35 years). Secondary outcomes included aetiology and 1-month survival. Logistic regression was used to identify factors associated with OHCA in females versus males.Results Among 18 767 OHCA cases, 6185 (33.0%) were females, 360 (1.92%) were paediatric patients, 1240 (6.61%) young adults and 17 167 (91.5%) older adults.In paediatric patient, male were older (6.00 vs 2.78 years, p=0.029) and had shorter no-flow times (5.00 vs 10.0 min, p=0.007). Among young adults, OHCA in males occurred more often in public areas (61.9% vs 35.3%, p<0.001) and during sport (6.47% vs 1.53%, p<0.001); females had shorter no-flow time (3.00 vs 5.00 min, p=0.035). In older adults, males were younger (64.3 vs 71.8 years, p<0.001), more shocked (40.2% vs 23.7%, p<0.001) and more commonly managed with amiodarone (16.5% vs 8.11%, p<0.001). OHCA in males occurred more often in public areas (33.9% vs 19.8%, p<0.001) and during sport (1.94% vs 0.30%, p<0.001).After adjustment, females underwent coronary angiography less often (OR (95% CI) 0.54 (0.46 to 0.64)). Survival to hospital discharge was lower in females across all age groups, reaching statistical significance in older adults (6.23% vs 9.37%, p<0.001).Conclusions Sex differences in OHCA characteristics and outcomes were observed across all age groups and became more pronounced with increasing age, consistently indicating a better prognosis for males.",
  "authors": [
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France"
      ],
      "name": "Delphine Lavignasse"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France"
      ],
      "name": "Emma Menant"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France"
      ],
      "name": "Georgios Sideris"
    },
    {
      "affiliations": [
        "Emergency Medical Department, Paris Fire Brigade, Paris, France"
      ],
      "name": "Sabine Lemoine"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France",
        "Medical Surgical Intensive Care Unit, Jacques Cartier Private Hospital, Massy, France"
      ],
      "name": "Wulfran Bougouin"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France"
      ],
      "name": "Frankie Beganton"
    },
    {
      "affiliations": [
        "Université Paris Cité, Paris, France",
        "Emergency Medical Services, Necker-Enfants Malades Hospitals, Paris, France"
      ],
      "name": "Patricia Jabre"
    },
    {
      "affiliations": [
        "Emergency Medical Services, Hospital Raymond-Poincaré, Garches, France"
      ],
      "name": "Thomas Loeb"
    },
    {
      "affiliations": [
        "Emergency Medical Services, Hospital Avicenne, Bobigny, France"
      ],
      "name": "Jean-Marc Agostinucci"
    },
    {
      "affiliations": [
        "Emergency Medical Services, Hospital Henri Mondor, Créteil, France"
      ],
      "name": "Eric Lecarpentier"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France",
        "Emergency Medical Department, Paris Fire Brigade, Paris, France"
      ],
      "name": "Daniel Jost"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France",
        "Medical Intensive Care Unit, Hopital Cochin, Paris, France"
      ],
      "name": "Alain Cariou"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France"
      ],
      "name": "Jean-Philippe Empana"
    },
    {
      "affiliations": [
        "Université Paris Cité, Inserm, PARCC, F-75015 Paris, France",
        "Department of Cardiology, European Hospital Georges Pompidou, Paris, France"
      ],
      "name": "Xavier Jouven"
    }
  ],
  "title": "Sex differences in out-of-hospital cardiac arrest across age groups",
  "uid": "537495fc-3718-57b3-bcfd-afc32d8b763f"
}