{
  "abstract": "Background Statistical shape atlases have been used in large-cohort studies to investigate relationships between heart shape and risk factors. The generalisability of these relationships between cohorts is unknown. The aims of this study were to compare left ventricular (LV) shapes in patients with differing cardiovascular risk factor profiles from two cohorts and to investigate whether LV shape scores generated with respect to a reference cohort can be directly used to study shape differences in another cohort.Methods Two cardiac MRI cohorts were included: 2106 participants (median age: 65 years, 54% women) from the Multi-Ethnic Study of Atherosclerosis (MESA) and 2960 participants (median age: 64 years, 52% women) from the UK Biobank (UKB) study. LV shape atlases were constructed from 3D LV models derived from expert-drawn contours from separate core labs. Atlases were considered generalisable for a risk factor if the area under the receiver operating characteristic curves (AUC) were not significantly different (p>0.05) between internal (within-cohort) and external (cross-cohort) cases.Results LV mass and volume indices were differed significantly between cohorts, even in age-matched and sex-matched cases without risk factors, partly reflecting different core lab analysis protocols. For the UKB atlas, internal and external discriminative performance were not significantly different for hypertension (AUC: 0.77 vs 0.76, p=0.37), diabetes (AUC: 0.79 vs 0.77, p=0.48), hypercholesterolaemia (AUC: 0.76 vs 0.79, p=0.38) and smoking (AUC: 0.69 vs 0.67, p=0.18). For the MESA atlas, diabetes (AUC: 0.79 vs 0.74, p=0.09) and hypercholesterolaemia (AUC: 0.75 vs 0.70, p=0.10) were not significantly different. Both atlases showed significant differences for obesity.Conclusions The MESA and UKB atlases demonstrated good generalisability for diabetes and hypercholesterolaemia, without requiring corrections for differences in mass and volume. Significant differences in obesity may be due to different relationships between obesity and heart shapes between cohorts.",
  "authors": [
    {
      "affiliations": [
        "Biomedical Engineering & Imaging Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK",
        "Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"
      ],
      "name": "Avan Suinesiaputra"
    },
    {
      "affiliations": [
        "Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand",
        "Mackie Research and Consulting, Auckland, New Zealand"
      ],
      "name": "Kathleen Gilbert"
    },
    {
      "affiliations": [
        "Biomedical Engineering & Imaging Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK",
        "Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"
      ],
      "name": "Charlene Mauger"
    },
    {
      "affiliations": [
        "Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"
      ],
      "name": "David A Bluemke"
    },
    {
      "affiliations": [
        "Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA"
      ],
      "name": "Colin O Wu"
    },
    {
      "affiliations": [
        "William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK",
        "Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK"
      ],
      "name": "Nay Aung"
    },
    {
      "affiliations": [
        "Oxford NIHR Biomedical Research Centre, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK"
      ],
      "name": "Stefan Neubauer"
    },
    {
      "affiliations": [
        "Oxford NIHR Biomedical Research Centre, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK"
      ],
      "name": "Stefan K Piechnik"
    },
    {
      "affiliations": [
        "Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK",
        "William Harvey Research Institute, Queen Mary University of London, London, UK"
      ],
      "name": "Steffen E Petersen"
    },
    {
      "affiliations": [
        "Cardiology Division of the Departments of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA"
      ],
      "name": "Joao A C Lima"
    },
    {
      "affiliations": [
        "Department of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA"
      ],
      "name": "Bharath Ambale Venkatesh"
    },
    {
      "affiliations": [
        "Biomedical Engineering & Imaging Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK",
        "Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"
      ],
      "name": "Alistair Young"
    }
  ],
  "title": "Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank",
  "uid": "02598661-597b-53ca-9c34-8d344a43bed3"
}