{
  "abstract": "Background Identifying significant coronary artery disease (CAD) in patients with reduced left ventricular ejection fraction (rLVEF) is essential for guiding therapeutic decisions, including medical management, device implantation and potential revascularisation. Prior studies suggested that rest cardiac MRI (CMR) with late gadolinium enhancement (LGE) could reliably detect significant CAD. We aimed to evaluate the diagnostic accuracy of rest LGE-CMR for predicting significant CAD in rLVEF patients.Methods In this prospective, multicentre cohort study across 10 centres, adults with new-onset rLVEF≤45% without obvious cause were included. All patients underwent rest CMR and coronary angiography. Independent, blinded committees reviewed images. Significant CAD was defined as ≥70% stenosis in major coronary arteries. Ischaemic scars were identified on CMR as subendocardial LGE. The primary outcome was the sensitivity of CMR in detecting significant CAD.Results Among 380 patients (median age 63 years, 68% male), significant CAD was present in 49 (13%). CMR identified ischaemic scars in 106 (28%). The sensitivity of CMR for detecting significant CAD was 57% (95% CI: 43% to 71%), specificity 76% (95% CI: 72% to 81%), positive predictive value 26% (95% CI: 18% to 35%) and negative predictive value 92% (95% CI: 89% to 95%). A CMR-first strategy would have missed 43% of significant CAD cases, many requiring revascularisation (86% of missed cases).Conclusions In this large, prospective multicentre study with independent image review, rest LGE-CMR demonstrated limited sensitivity for detecting significant CAD in patients with rLVEF. Relying solely on CMR could lead to missed diagnoses and undertreatment. CMR should be integrated with other diagnostic tools to optimise care in this population.Trial registration number NCT03231189.",
  "authors": [
    {
      "affiliations": [
        "Cardiology Department, La Réunion University Hospital, Saint-Denis, France",
        "CIC-EC INSERM1410, La Réunion University Hospital, Saint-Denis, France"
      ],
      "name": "Louis-Marie Desroche"
    },
    {
      "affiliations": [
        "Cardiology Department, Centre Cardiologique du Nord, Saint-Denis, France"
      ],
      "name": "Arthur Darmon"
    },
    {
      "affiliations": [
        "Cardiology Department, Toulouse University Hospital, Toulouse, France"
      ],
      "name": "Yoan Lavie-Badie"
    },
    {
      "affiliations": [
        "Radiology Department, Nancy University Hospital, Nancy, France"
      ],
      "name": "Damien Mandry"
    },
    {
      "affiliations": [
        "Bichat - Claude-Bernard Hospital Cardiology Service, Paris, France",
        "INSERM U1148 LVTS, Bichat Hospital, Paris, France",
        "French Alliance for Cardiovascular Trials (FACT), Paris, France",
        "Paris University, Paris, France"
      ],
      "name": "Gregory Ducrocq"
    },
    {
      "affiliations": [
        "Cardiology Department, La Réunion University Hospital, Saint-Denis, France"
      ],
      "name": "Thiziri Si-Moussi"
    },
    {
      "affiliations": [
        "Clinical Research Unit-Health Economics (URC-Eco), APHP, Paris, France",
        "INSERM 1153 CRESS Research Center in Epidemiology and Statistics, Sorbonne Paris Cité, Paris, France"
      ],
      "name": "Isabelle Durand-Zaleski"
    },
    {
      "affiliations": [
        "Cardiology Department, Montfermeil Hospital, Montfermeil, France"
      ],
      "name": "Damien Millischer"
    },
    {
      "affiliations": [
        "Bichat - Claude-Bernard Hospital Cardiology Service, Paris, France"
      ],
      "name": "Olivier Milleron"
    },
    {
      "affiliations": [
        "Cardiology Department, Nancy University Hospital, Nancy, France",
        "INSERM U1116, Nancy University Hospital, Nancy, France",
        "Lorraine University, Nancy, France",
        "CIC-1433, Nancy Hospital, Nancy, France"
      ],
      "name": "Olivier Huttin"
    },
    {
      "affiliations": [
        "Cardiology Department, Mercy Hospital, CHR Metz-Thionville, Metz, France"
      ],
      "name": "Mathieu Valla"
    },
    {
      "affiliations": [
        "Cardiology Department, Centre Hospitalier Annecy Genevois, Epagny Metz-Tessy, France"
      ],
      "name": "Lionel Mangin"
    },
    {
      "affiliations": [
        "Cardiology Department, Pasteur Clinic, Toulouse, France"
      ],
      "name": "Bruno Farah"
    },
    {
      "affiliations": [
        "Cardiology Department, Institut Mutualiste Montsouris, Paris, France"
      ],
      "name": "Christelle Diakov"
    },
    {
      "affiliations": [
        "Cardiology, Universitary Hospital Saint-Louis – Lariboisière – Fernand-Widal, AP-HP, Paris, France"
      ],
      "name": "Damien Logeart"
    },
    {
      "affiliations": [
        "Hopital Montfermeil, Montfermeil, France"
      ],
      "name": "Benjamin Safar"
    },
    {
      "affiliations": [
        "Radiology Department, La Réunion University Hospital, Saint-Denis, France"
      ],
      "name": "Jean-Yves Travers"
    },
    {
      "affiliations": [
        "Bichat - Claude-Bernard Hospital Cardiology Service, Paris, France"
      ],
      "name": "Jules Mesnier"
    },
    {
      "affiliations": [
        "Clinical Research Unit-Health Economics (URC-Eco), APHP, Paris, France"
      ],
      "name": "Alexandra Vappereau"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Biostatistics and Clinical Research, Bichat Hospital, Paris, France"
      ],
      "name": "Toni Alfaiate"
    },
    {
      "affiliations": [
        "Department of Epidemiology, Biostatistics and Clinical Research, Bichat Hospital, Paris, France",
        "CIC 1425, Bichat Hospital, Paris, France"
      ],
      "name": "Charles Burdet"
    },
    {
      "affiliations": [
        "Bichat - Claude-Bernard Hospital Cardiology Service, Paris, France",
        "INSERM U1148 LVTS, Bichat Hospital, Paris, France",
        "Paris University, Paris, France"
      ],
      "name": "Guillaume Jondeau"
    },
    {
      "affiliations": [],
      "name": "on behalf of the CAMAREC investigators"
    }
  ],
  "title": "Diagnostic accuracy of late gadolinium enhancement cardiac MRI for coronary artery disease in patients with reduced left ventricular ejection fraction",
  "uid": "d0f32efc-cdd8-5aff-9c59-d0533878be8f"
}