{
  "abstract": "Background Dilated cardiomyopathy (DCM) is a progressive myocardial disease characterized by ventricular dilation and impaired systolic function, often leading to heart failure and increased mortality. This study aims to analyze DCM-related mortality trends among adults in the United States from 1999 to 2023.Methods Trends in DCM-related mortality among adults aged ≥ 25 years from 1999 to 2023 were analyzed using the CDC WONDER multiple-cause of death database. Age adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated and stratified by year, sex, race, census region and urbanization status.Results From 1999 to 2023, there were 184,073 deaths in the United States attributed to DCM. Over this period, the AAMR declined from 5.19 in 1999 to 2.34 in 2023. Between 1999 and 2002, the AAMR decreased significantly from 5.19 to 4.38 (APC -6.20* [95% CI, -12.42 to -0.72; P = 0.0208]). The trend remained stable between 2002 and 2005, followed by a significant decline between 2005 and 2014, where the AAMR decreased from 4.96 to 2.66 (APC -6.84* [95% CI, -9.00 to -3.05; P = 0.0300]). The trend then remained relatively unchanged from 2014 to 2023 ( figure 1). In 2023, males (3.4) averaged a considerably higher AAMR than females (1.38) (figure 1). Among racial groups, the highest AAMR in 2023 was reported in the Non-Hispanic (NH) Black group (3.77), followed by the NH White group (2.3), the Hispanics and Latinos (1.67) and the NH Others group (NH Asians and NH Native American Indian or Alaskan Native) at 1.23 (figure 2). Overall from 1999 to 2020, rural areas (3.52) averaged a significantly higher AAMR than urban areas (3.50). Regionally, in 2023, the Western region averaged the highest AAMR at 2.69, followed by the South at 2.31, the Midwest at 2.42 and lastly the Northeast at 1.83.Abstract 1-014 Figure 1Trends in dilated cardiomyopathy-related mortality in the United States (1999–2023), stratified by overall population and sexAbstract 1-014 Figure 2Trends in dilated cardiomyopathy-related mortality in the United States (1999–2023), stratified by raceConclusion Our analysis revealed a significant decline in DCM-related mortality rates in the United States from 1999 to 2023, with the most substantial reductions occurring between 1999 and 2014. However, disparities persist, with higher mortality rates observed in males, NH Black individuals, and rural populations. Regional variations also highlight the need for targeted interventions to further reduce the burden of DCM.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine, Sheikh Shakhbout Medical City, UAE"
      ],
      "name": "Babikar Elsiraj"
    },
    {
      "affiliations": [
        "Department of Medicine, Amna Inayat Medical College, Sheikhupura, Pakistan"
      ],
      "name": "Zian Zafar Cheema"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Department of Medicine, The Specialty Hospital, Amman, Jordan"
      ],
      "name": "Mohammad Atout"
    },
    {
      "affiliations": [
        "Department of Medicine, David Tvildiani Medical University, Tbilisi, Georgia"
      ],
      "name": "Taha Kassim Dohadwala"
    },
    {
      "affiliations": [
        "Department of Medicine, Sheikh Shakhbout Medical City, UAE"
      ],
      "name": "Ahmed Talaat Deiab"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Zayed Military Hospital, Abu Dhabi, UAE"
      ],
      "name": "Aya Abouayana"
    },
    {
      "affiliations": [
        "Department of Medicine, Jordan University Hospital, Amman, Jordan"
      ],
      "name": "Hazim Mesmar"
    },
    {
      "affiliations": [
        "Department of Medicine, Prince Hamzeh Hospital, Amman, Jordan"
      ],
      "name": "Asmaa Hasan"
    },
    {
      "affiliations": [
        "Department of Medicine, Newcastle Medical School, Newcastle, UK"
      ],
      "name": "Amaad Alam Shah"
    },
    {
      "affiliations": [
        "Department of Trauma and Orthopaedics, Sunderland Royal Hospital, Sunderland, UK"
      ],
      "name": "Muhammad Babar Mahmood"
    },
    {
      "affiliations": [
        "Department of Medicine, Imperial College London, London, UK"
      ],
      "name": "Hasan Ahmed"
    },
    {
      "affiliations": [
        "Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan"
      ],
      "name": "Maryam Shahzad"
    },
    {
      "affiliations": [
        "Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"
      ],
      "name": "Mushood Ahmed"
    },
    {
      "affiliations": [
        "National Heart & Lung Institute, Imperial College London, London, UK",
        "Department of Cardiology, Royal Brompton Hospital, London, UK"
      ],
      "name": "Raheel Ahmed"
    }
  ],
  "title": "1-014 Trends and disparities of dilated cardiomyopathy among adults in the United States: a CDC wonder analysis (1999–2023)",
  "uid": "e5c58a9f-032f-5122-a776-841dd73aea52"
}