{
  "abstract": "Introduction QRISK3 (2018), based on UK data, is able to estimate the 10-year risks of major adverse cardiac events [MACE] in people aged 25–84, to permit individualised risk stratification. Lipid profiles may also assess cardiac risk. We identified patients with myocardial infarction (MI) in a multiethnic area of socioeconomic deprivation, and retrospectively evaluated the ability of QRISK3 and lipid profile to predict the subsequent event.Methods Study: Retrospective observational study.Cohort: Patients with acute coronary syndrome aged 25 – 84.Case selection: Identification of consecutive events of myocardial infarction. Assessment of angiogram to confirm flow limiting disease. Total 284 events. Recurrent events and patients aged > 84 excluded, resulting in 245 patients.Data: QRISK3 scores. LDL. Demographics. Prior cardiac status. Other cardiac risk factors.Analysis: Descriptive statistics [mean±SEM], t-test and ANOVA [n.s. p>0.05, * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001].Results Mean age was 64±0.69, with male 178 [72.7%]. 106 [43.3%] had prior MACE. Mean QRISK-3 score was 25.0±0.82.We found a significant disparity between proportions of populations presenting. Caucasian and South Asian patients had much higher incidence of presentation than their population base would suggest, and of an equivalent factor [table 1]. This is despite QRISK3 score for Caucasian patients (23.6±1.0) being significantly lower than that for the South Asian population (29.4±1.5, p = 0.0007), and comparable with other ethnicities, who have a much lower proportion of presentation [figure 1].Abstract 7-033 Table 1Ethnic Breakdown in catchment area [based on 2021 census] and presenting with MI. Ethnic Index of MI = % presenting with MI / % in catchment area Catchment area Presenting with MI Ethnic Index of MI Other 3.4% 0.02% 0.6 East Asian 0.4% 0.01% 2.5 African 10% 0.02% 0.2 Caucasian 45.2% 60.4% 133.6 South Asian 36.9% 35.5% 96.2 Abstract 7-033 Figure 1QRISK score by ethnicityQRISK3 combines multiple cardiac risk factors, including lipid profile. However, when dividing the population by low (<2.0) and high LDL (≥2.0 mmol/L) we found higher QRISK3 in the low LDL group (26.7±1.2 vs 22.5±1.3, p = 0.02). LDL vs prior MACE status [figure 2] shows significantly lower LDL in those undergoing secondary prevention. QRISK3 was higher in prior MI (28.9±1.2 vs 22.85±1.0, p = 0.02).Abstract 7-033 Figure 2Lipid profile by prior MACE statusConclusions A high percentage of patients were Caucasian [64% of males, 66% of females]. The Ethnic Index indicates disproportionate attendance from Caucasian and South Asian groups. The South Asian ethnic group had the highest QRISK3 [p < 0.0001].Patients with low LDL levels (<2.0) had a 52.1% incidence of prior MI, compared to 27.7% with higher LDL (>/= 2.0). This could be interpreted as patients with first MI having not been previously identified in primary prevention, or highly active secondary prevention to lower LDL after MI.Unequal rates of presentation by ethnicity, and poor lipid control in first MI, highlight the need for targeted preventative care in our population.",
  "authors": [
    {
      "affiliations": [
        "Luton and Dunstable Hospital, UK"
      ],
      "name": "KD Rai"
    },
    {
      "affiliations": [
        "Luton and Dunstable Hospital, UK"
      ],
      "name": "G Kumar"
    },
    {
      "affiliations": [
        "Luton and Dunstable Hospital, UK"
      ],
      "name": "SA Edroos"
    }
  ],
  "title": "7-033 Predictability of cardiovascular events in a multi-ethnic cohort with qrisk3 score and low density lipoprotein: a retrospective observational study",
  "uid": "ad5bdb4b-0246-56e0-8714-f5fecf9125e4"
}