{
  "abstract": "Background Myocardial infarction is a leading cause of death in both men and women. Previous studies have demonstrated higher mortality in women following ST elevation myocardial infarction (STEMI) but there are few long-term follow-up studies. 1 Purpose We analysed the 10-year outcomes of a population of patients treated with primary PCI (PPCI) for STEMI, with a focus on short and long-term mortality delineated by gender.Methods We identified all patients treated with PPCI for STEMI during 2014 in the Belfast Heart Attack Centre. Follow-up clinical data were extracted from the Northern Ireland Electronic Care Record, a comprehensive regional record which covers all patients in the region. We used Kaplan-Meier time-to-event analysis to estimate the cumulative incidence of death and then adjusted for covariates using a Cox proportional hazards regression model. Data were analysed using SPSS V.28.0.Results Six-hundred and ninety-one patients (mean age 64 +/- SD13 years; 25.4% female) who underwent PPCI during 2014 were followed for a median of 10.5 years. Female patients were older at presentation (70 +/- SD 14 years vs 62 +/- SD13 years: P<0.001) and had higher rates of chronic kidney and lung disease at baseline (both P<0.01).All-cause mortality at 30-days, 1 year and 10-years after PPCI were 5.6%, 6.6% and 33.4% respectively in males and 6.9%,10.9% and 46.9% respectively in females (figure 1a) Unadjusted mortality was higher in women at 1 year (HR 1.9 [95% CI: 1.1 to 3.5: p=0.018]) and 10 years (HR 1.7 [95% CI 1.3 to 2.2: p<0.001]). After adjusting for age at presentation, no difference in mortality was observed (HR 1.1 [95% CI 0.8 to 1.5: P=NS]) (figure 1b).Abstract 2-041 Figure 1Kaplan Meier curves demonstrating 10-year survival followoing primary PCI for STEMI in males and females. a) Unadjusted survival and b) after adjustment for age at presentationConclusion After adjustment for age at presentation we found no gender difference in short or long term mortality in unselected patients undergoing PPCI for STEMI.Reference Xi Z, Qiu H, Guo T, Wang Y, Li J, Li Y, Zheng J, Gao R. Contemporary sex differences in mortality among patients with ST-segment elevation myocardial infarction: a systematic review and meta-analysis. BMJ Open. 2022 Mar 9;12(3):e053379. doi: 10.1136/bmjopen-2021-053379. PMID: 35264344; PMCID: PMC8915368.",
  "authors": [
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "P Savage"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "Brian Cox"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "J Ruddell"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "M McKane"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "C Brines"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "S McCance"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "B McGowan"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "M Todd"
    },
    {
      "affiliations": [
        "Cork University Hospital, Cork"
      ],
      "name": "J Laffan"
    },
    {
      "affiliations": [
        "Royal Victoria Hospital, Belfast"
      ],
      "name": "N Herity"
    }
  ],
  "title": "2-041 Age at presentation explains gender differences in mortality after primary PCI for STEMI. A ten year follow-up study",
  "uid": "4aac822c-1313-5c04-ae66-7e28d1e53e12"
}