{
  "abstract": "Background Rising antibiotic resistance challenges the selection of first-line eradication regimens for Helicobacter pylori (H. pylori). The comparative efficacy of high-dose dual therapy (DT) and various bismuth quadruple therapies (BQT) remains controversial. This study aimed to compare the real-world efficacy of DT and four BQT regimens in treatment-naive patients, and to evaluate the impact of gender and age on outcomes.Methods This study included 551 treatment-naive H. pylori patients. Based on their clinical prescriptions, patients were divided into five groups: DT, and BQTs based on minocycline (MIN-BQT), clarithromycin (CLA-BQT), furazolidone (FUR-BQT), or doxycycline (DOX-BQT). Clinical data, including gender, age and eradication outcomes, were collected. Eradication rates were compared using Chi-square tests, and independent factors affecting efficacy were evaluated via multivariable logistic regression.Results For treatment-naive H. pylori infections, the combined BQT regimens achieved a significantly higher eradication rate than DT (P = 0.019, IDDF2026-ABS-0527 Figure 1(A) Efficacy Evaluation and Multivariable Analysis of Different Eradication Regimens for Treatment-Naive Helicobacter pylori). Significant efficacy differences were observed among the five groups: both MIN-BQT and DOX-BQT outperformed DT. Notably, MIN-BQT demonstrated the highest efficacy, significantly superior to traditional CLA-BQT and FUR-BQT (all P < 0.05, IDDF2026-ABS-0527 Figure 1(B) Efficacy Evaluation and Multivariable Analysis of Different Eradication Regimens for Treatment-Naive Helicobacter pylori). Subgroup analyses indicated that gender and age had no significant impact on the efficacy of the regimens. Multivariable logistic regression further confirmed that, after adjusting for age and gender, the treatment regimen remained a significant independent factor affecting the H. pylori eradication outcome (IDDF2026-ABS-0527 Figure 1(C) Efficacy Evaluation and Multivariable Analysis of Different Eradication Regimens for Treatment-Naive Helicobacter pylori).Conclusions These findings show that BQT generally outperforms DT for treatment-naive H. pylori infections. MIN-BQT achieves the highest eradication rate independent of patient gender and age. This study proves the high efficacy of novel BQTs in the era of antibiotic resistance and provides crucial evidence-based support for optimizing empirical first-line therapies. MIN-BQT is recommended as an optimal first-line strategy.Abstract IDDF2026-ABS-0527 Figure 1",
  "authors": [
    {
      "affiliations": [
        "The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, China"
      ],
      "name": "Fan Xu"
    },
    {
      "affiliations": [
        "Xuzhou Medical University, China"
      ],
      "name": "Chuyan Li"
    },
    {
      "affiliations": [
        "The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, China"
      ],
      "name": "Ru Feng"
    },
    {
      "affiliations": [
        "The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, China"
      ],
      "name": "Rui Xie"
    },
    {
      "affiliations": [
        "The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, China"
      ],
      "name": "Honggang Wang"
    }
  ],
  "title": "IDDF2026-ABS-0527 Efficacy and influencing factors of different eradication regimens for treatment-naive helicobacter pylori in clinical practice",
  "uid": "812efe7f-960d-52ba-94a7-b0b0f43fd530"
}