{
  "abstract": "Background Pancreatic exocrine insufficiency (PEI) has been linked to an elevated risk of fatty liver disease. However, its relationship with metabolic dysfunction-associated fatty liver disease (MAFLD) in the general population is not well-defined. This study aims to characterize and compare the clinical profiles of patients with different combinations of PEI and MAFLD status.Methods The study cohort was divided into three groups according to the PEI and MAFLD status: Group ( FL/PEI), patients with both MAFLD and PEI; Group (FL), patients with only MAFLD; Group (PEI), patients with only PEI. Clinical characteristics were compared across these groups. Statistical analyses were performed using SPSS 28.0. (IDDF2026-ABS-0306 Figure 1. Flowchart of the research process)Results Overall, 669 cases (mean age 69.37 ± 6.34 years, 41.11% men) were recruited. Compared with Group ( FL), Group (FL/PEI) had significantly lower risks of elevated serum total cholesterol (TC; OR 0.518, 95%CI 0.283 to 0.947, P = 0.033) and elevated low-density lipoprotein cholesterol (LDL-c; OR 0.476, 95%CI 0.231 to 0.983, P = 0.045) (IDDF2026-ABS-0306 Figure 2. Multiple stepwise logistic regression analysis of the risk of elevated serum cholesterol levels across different groups divided by PEI and MAFLD after adjusting covariates. (A) The risk of elevated TC (B) The risk of elevated LDL-c). Among PEI patients, obese individuals face a significantly higher risk of MAFLD compared to those with a normal body mass index (BMI; OR 4.061, 95%CI 1.813 to 9.097, P = 0.001). In patients with MAFLD, males had a significantly higher risk of PEI (OR 1.856, 95%CI 1.061 to 3.247, P = 0.030).Conclusions Impaired cholesterol absorption may be a cause of PEI-induced fatty liver. PEI patients with obesity face an elevated risk of developing MAFLD, while in patients with MAFLD, the gender differences in PEI warrant further investigation.Abstract IDDF2026-ABS-0306 Figure 1Abstract IDDF2026-ABS-0306 Figure 2",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
      ],
      "name": "Yaya Bai"
    },
    {
      "affiliations": [
        "Department of General Medicine, Beicai Community Health Service Center of Pudong New Area, Shanghai, China"
      ],
      "name": "Jiajia Xu"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Changhai Hospital, Shanghai, China"
      ],
      "name": "Xiaoyu Zhou"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Changhai Hospital, Shanghai, China"
      ],
      "name": "Xi He"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Changhai Hospital, Shanghai, China"
      ],
      "name": "Lianghao Hu"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
      ],
      "name": "Chunhua Zhou"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Changhai Hospital, Shanghai, China"
      ],
      "name": "Zhaoshen Li"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
      ],
      "name": "Duowu Zou"
    }
  ],
  "title": "IDDF2026-ABS-0306 Pancreas-liver crosstalk: a population-based study on the clinical characteristics of patients with different statuses of fatty liver and pancreatic exocrine insufficiency",
  "uid": "79176551-9665-56b4-8224-33823deaaff5"
}