{
  "abstract": "Introduction Colon capsule endoscopy (CCE) is an established non-invasive alternative to colonoscopy, but its optimal role in intermediate-risk faecal immunochemical test (FIT)-positive and surveillance populations, particularly in younger adults, remains uncertain.Methods An interim retrospective analysis was conducted of adults aged 18–60 years undergoing CCE for intermediate-risk FIT (10-100 µg Hb/g) or post-polypectomy/CRC(colorectal cancer) surveillance. Primary outcomes were colorectal neoplasia detection, incomplete/failed procedures, and colonoscopy conversion rates. Outcomes were compared between FIT-positive and surveillance groups and stratified by age (≤50 vs 50-60 years). The data was collected as part of a NHS England funded pilot projectResults Forty-seven patients were included (median age 46 years, 51% males); 20 were FIT-positive and 23 under surveillance. Other groups(n=4) included patients unable to tolerate optical colonoscopy. Overall, CCE identified colorectal cancer in 1 patient(60 year old in the FIT-positive group) and polyps in 11 patients with 4 incomplete/failed procedures. Colonoscopy conversion in FIT-positive patients was 15%, including 1 for colonic inflammation and 1 incomplete study, whereas conversion was higher in the surveillance group (30%) and in those aged 50–60 years (39%). Conversion rates were lowest in younger intermediate-risk FIT-positive patients, supporting CCE as a suitable triage modality in this subgroup.Conclusions CCE demonstrated favourable diagnostic yield with low colonoscopy conversion rates in younger patients, particularly those who were intermediate-risk FIT-positive. These data support the use of CCE as a preliminary investigation in this cohort, with colonoscopy reserved for older patients(≥50 years of age) or where therapeutic intervention is required, thereby optimising colonoscopy resource utilisation and patient experience. The higher conversion rate in surveillance colonoscopy group would also reflect the older age in this cohort. Additional data evaluation with greater number of patients on completion of the pilot project would be needed.",
  "authors": [
    {
      "affiliations": [
        "Ashford and St Peter’s Hospitals NHS Foundation Trust, Chertsey, United Kingdom"
      ],
      "name": "Debabrata Majumdar"
    },
    {
      "affiliations": [
        "Ashford and St Peter’s Hospitals NHS Foundation Trust, Chertsey, United Kingdom"
      ],
      "name": "Mardy Mendoza"
    },
    {
      "affiliations": [
        "Ashford and St Peter’s Hospitals NHS Foundation Trust, Chertsey, United Kingdom"
      ],
      "name": "Shriya Vishwanathan"
    }
  ],
  "title": "P37 Colon capsule endoscopy as a first-line test in younger intermediate-risk FIT-positive patients",
  "uid": "a4ddedf1-cff9-5c58-8f9d-fbe0a2c6b94d"
}