{
  "abstract": "Methods This is a retrospective study. We included 14 of 176 patients with Wilson’s disease who met the transplant criteria and underwent liver transplantation. Preoperative, intraoperative, and postoperative parameters were analyzed, and patients were followed up until January 2026.Results In 14 patients who underwent transplantation, the median age was 16.2 years (IQR 13.7–31.8), and 13 patients were male. Indications included one patient (7.1%) with acute liver failure, two (14.3%) with acute-on-chronic liver failure, and the remaining 11 patients (78.6%) had decompensated cirrhosis. The median MELD-Na score was 15.0 (IQR 11.0–22.3). In patients with cirrhosis, eight patients (57.1%) were Child–Pugh class B, and six (42.9%) were Child–Pugh class C. Three patients (21.4%) received left-lobe grafts, while 11 (78.6%) received right-lobe grafts. Median GRWR was 1.15. The median cold ischemia time was 38 minutes (IQR 28–51). Single-duct biliary anastomosis was performed in eight patients (57.1%), and double-duct anastomosis in six patients (42.9%). Three patients (21.4%) required re-exploration due to surgical complications. Five patients (35.7%) experienced acute T-cell–mediated rejection. Three patients (21.4%) died with sepsis as the major cause. No deaths were attributed to primary graft non-function or any vascular complications. Three patients (21.4%) experienced worsening neurological symptoms, and four patients (28.6%) experienced worsening psychiatric symptoms after Liver transplantation.Kaplan–Meier survival was 78.6% overall, 66.7% among patients with postoperative sepsis, 85.7% among patients requiring ERCP (compared with 71.4% in patients without ERCP), and 80% in recipients of right-lobe grafts (compared with 75% in left-lobe grafts).Conclusions Even in a resource-constrained setting, liver transplantation offered to patients with Wilson’s disease had comparable and favorable outcomes when compared to European registry data of post liver transplantation in Wilson’s disease. Patient factors, including postoperative infection and left liver lobe grafts, were associated with poorer survival. Acute T-cell–mediated rejection, when appropriately managed, did not appear to affect survival. More data is needed to verify the results.",
  "authors": [
    {
      "affiliations": [
        "Pakistan Kidney and Liver Institution Lahore, Lahore, Pakistan"
      ],
      "name": "Bilal Shoukat"
    },
    {
      "affiliations": [
        "Pakistan Kidney and Liver Institution Lahore, Lahore, Pakistan"
      ],
      "name": "Yumnah Riaz"
    },
    {
      "affiliations": [
        "Pakistan Kidney and Liver Institution Lahore, Lahore, Pakistan"
      ],
      "name": "Swaiba Samar"
    },
    {
      "affiliations": [
        "Pakistan Kidney and Liver Institution Lahore, Lahore, Pakistan"
      ],
      "name": "Ammara Naveed"
    },
    {
      "affiliations": [
        "Pakistan Kidney and Liver Institution Lahore, Lahore, Pakistan"
      ],
      "name": "Ahmad Karim Malik"
    },
    {
      "affiliations": [
        "Pakistan Kidney and Liver Institution Lahore, Lahore, Pakistan"
      ],
      "name": "Usman Aujla"
    }
  ],
  "title": "P115 Liver transplant outcomes in patients with Wilson’s disease from a single-centre, resource-limited setting",
  "uid": "8de00df7-4bf1-5ee2-accf-f3d49e220722"
}