{
  "abstract": "Background Post-infection disorders of gut-brain interaction (PI-DGBI) are a subset of chronic gastrointestinal disorders triggered by acute infectious gastroenteritis. These conditions impose a significant burden on patients’ quality of life.Objectives This study aimed to determine the prevalence of PI-DGBI and assess associated risk factors among participants in the Rome Foundation Global Epidemiology Study.Design Data were extracted from an online survey involving 54 127 participants across 26 countries. PI-DGBI were diagnosed based on self-reported gastrointestinal symptoms following acute gastroenteritis. Statistical analyses included multivariate logistic regression to identify factors associated with PI-DGBI and comparisons with DGBI not associated with infection.Results Of 21 713 individuals with at least one DGBI, 987 (10.5%) were classified as having PI-DGBI. PI-DGBI prevalence varied geographically, with the highest rates in Asia (7.1%) and Latin America (6.4%). Younger age, male sex, urban residence, anxiety and higher somatic symptom scores were positively associated with subjects reporting PI-DGBI, while female sex and rural living had negative associations. Subjects with PI-DGBI reported more severe psychological and physical health impairments and distinct gastrointestinal profiles, including higher rates of functional dyspepsia (32.2%), irritable bowel syndrome (23.5%) and anorectal disorders (35.3%).Conclusions PI-DGBI represents a significant subset of DGBI, with distinct sociodemographic and clinical characteristics. These findings highlight the role of acute gastroenteritis in triggering the onset of long-term gastrointestinal disorders and underscore the need for targeted interventions to mitigate its impact on patient health.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, University of Bologna, Bologna, Emilia-Romagna, Italy",
        "IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Emilia-Romagna, Italy"
      ],
      "name": "Giovanni Marasco"
    },
    {
      "affiliations": [
        "Laboratory of Neurogastroenterological Disorders, Unit of Experimental Medicine, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Mexico City, Ciudad de México, Mexico"
      ],
      "name": "Max Schmulson"
    },
    {
      "affiliations": [
        "Institute of Gastrosciences and Liver Transplantation, Apollo Multispeciality Hospitals Kolkata, Kolkata, WB, India"
      ],
      "name": "Uday C Ghoshal"
    },
    {
      "affiliations": [
        "Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada"
      ],
      "name": "Rutaba Khatun"
    },
    {
      "affiliations": [
        "Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada"
      ],
      "name": "Shrikant I Bangdiwala"
    },
    {
      "affiliations": [
        "IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Emilia-Romagna, Italy"
      ],
      "name": "Cesare Cremon"
    },
    {
      "affiliations": [
        "Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"
      ],
      "name": "Olafur S Palsson"
    },
    {
      "affiliations": [
        "Faculty of Health Sciences, Ben-Gurion University of the Negev, Be’er Sheva, South District, Israel"
      ],
      "name": "Ami D Sperber"
    },
    {
      "affiliations": [
        "Department of Medical and Surgical Sciences, University of Bologna, Bologna, Emilia-Romagna, Italy",
        "IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Emilia-Romagna, Italy"
      ],
      "name": "Giovanni Barbara"
    }
  ],
  "title": "Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study",
  "uid": "f98b6347-2b2a-5020-bd77-495d66331cc1"
}