{
  "abstract": "Intrahepatic cholangiocarcinoma (ICC) is a highly lethal primary liver tumour for which systemic therapies offer limited survival benefit.1–3 Over the past few decades, several signalling pathways associated with ICC development and progression have been identified. These molecular cascades affect the various characteristics of malignant cholangiocytes, including proliferation, survival, invasion, metastasis and metabolism.1–5 Thus, delineation of these pathways and their crosstalk may aid tailoring innovative therapies for this challenging disease.",
  "authors": [
    {
      "affiliations": [
        "Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA",
        "Research, Richmond VA Medical Center, Richmond, Virginia, USA"
      ],
      "name": "Huiping Zhou"
    },
    {
      "affiliations": [
        "Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA"
      ],
      "name": "Hui Li"
    },
    {
      "affiliations": [
        "Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA"
      ],
      "name": "Nan Wu"
    },
    {
      "affiliations": [
        "Institute of Pathology, University of Regensburg, Regensburg, Germany"
      ],
      "name": "Diego F Calvisi"
    }
  ],
  "title": "SIRT6–GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinoma",
  "uid": "376af50c-8820-5ecf-964a-d909e315a901"
}