{
  "abstract": "We read with great interest the recent Gut article by Yang and colleagues showing that SMYD2 acts as a hepatoprotective regulator during hepatic ischaemia/reperfusion (I/R) injury. In paired human hepatectomy samples, higher post-I/R SMYD2 expression was associated with better postoperative liver function. Mechanistically, the authors identify SMYD2-mediated STAT1 methylation at lysine 175 as a brake on STAT1 phosphorylation and nuclear translocation, thereby limiting inflammatory and apoptotic signalling in hepatocytes.1",
  "authors": [
    {
      "affiliations": [
        "Hepatology and Gene Therapy Program, Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET - Universidad Austral, Pilar, Buenos Aires Province, Argentina",
        "Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires, Argentina"
      ],
      "name": "Juan Bayo"
    },
    {
      "affiliations": [
        "Hepatology and Gene Therapy Program, Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET - Universidad Austral, Pilar, Buenos Aires Province, Argentina",
        "Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires, Argentina",
        "Spectrum Regenerative (HZ4 Liver Inc.), Miami, FL, USA"
      ],
      "name": "Barbara Bueloni"
    },
    {
      "affiliations": [
        "Hepatology and Gene Therapy Program, Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET - Universidad Austral, Pilar, Buenos Aires Province, Argentina",
        "Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires, Argentina"
      ],
      "name": "Esteban Fiore"
    },
    {
      "affiliations": [
        "Hepatology and Gene Therapy Program, Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET - Universidad Austral, Pilar, Buenos Aires Province, Argentina",
        "Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires, Argentina",
        "Liver Unit, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina"
      ],
      "name": "Guillermo Mazzolini"
    }
  ],
  "title": "Context matters for SMYD2 in liver disease: from hepatoprotection to tumour immune escape",
  "uid": "a598f345-3b64-5fdc-b62b-77b440ef4521"
}